NFL Picks Week 7: Latest Vegas Lines, Odds and Predicting Winners, Final Scores

Week 7 of the NFL season is almost upon us, and it's time to set your fantasy lineups and make your picks. 

On paper, this is one of the most lopsided set of games we'll see all season, as only four matchups currently have a spread within three points. 

Part of the reason for the lack of intriguing matchups this week is due to the fact that three of the league's unbeatens are on their bye. The Broncos, Bengals and Packers are all resting this week, joined by the 2-4 Bears.

Here's a look at the most recent spreads, courtesy of Odds Shark, followed by predictions for some of the most intriguing games of the week.

Day/Time (ET)	Matchup (Spread)	ATS Pick
Thurs. 8:25 p.m.	Seahawks (-6.5) at 49ers	SEA
Sun. 9:30 a.m.	Bills (-7) vs. Jaguars in London	JAC
Sun. 1 p.m.	Browns at Rams (-5.5)	CLE
Sun. 1 p.m.	Vikings (-2.5) at Lions	DET
Sun. 1 p.m.	Texans at Dolphins (-4)	MIA
Sun. 1 p.m.	Saints at Colts (-4.5)	IND
Sun. 1 p.m.	Steelers at Chiefs	--
Sun. 1 p.m.	Jets at Patriots (-10)	NYJ
Sun. 1 p.m.	Buccaneers at Redskins (-3)	WSH
Sun. 1 p.m.	Falcons (-4) at TItans	ATL
Sun. 4 p.m.	Raiders at Chargers (-4)	SD
Sun. 4:25 p.m.	Cowboys at Giants (-3)	DAL
Sun. 8:30 p.m.	Eagles at Panthers (-3)	CAR
Mon. 8:30 p.m.	Ravens at Cardinals (-9)	BAL

Note: Due to the uncertainty of Ben Roethlisberger's status, the Chiefs-Steelers game is off the board according to OddsShark.com as of Wednesday morning. No against-the-spread pick has been given for this game. 

Notable Games

Seattle Seahawks (-6.5) at San Francisco 49ers 

Elaine Thompson/Associated Press

What was briefly one of the best rivalries in all of football has been reduced to a battle for last place this season. 

The Seahawks and 49ers are both currently tied in the NFC West basement at 2-4, hoping to salvage their season with a division win on Thursday night. 

"

Pete Carroll said he's buoyed by players' calling to stay together in locker room: "With our history...ain't nothing over." #Seahawks

— Gregg Bell (@gbellseattle) October 18, 2015"

Despite their slow start, the Seahawks are heavily favored, and rightfully so.

Colin Kaepernick is just 1-5 in his career against the Seahawks and led the 49ers to just 10 points in two games last season against Seattle.

The 49ers offense has picked up a bit as of late, with 52 combined points in San Francisco's last two games against the Ravens and Giants. However, the 49ers have not fared well against the toughest defenses on their schedule. 

Against the Packers and Cardinals, San Francisco managed to score just 10 points combined. 

With a 2-4 record, the Seahawks have their back against the wall, but the talent to contend is clearly still there. This could be an opportunity for Pete Carroll's crew to make a statement against a division rival. 

Prediction: Seahawks 24, 49ers 10

Buffalo Bills (-7) vs. Jacksonville Jaguars in London

Bill Wippert/Associated Press

Based purely on talent, it's not hard to see why the Bills are a touchdown favorite over Jacksonville. But this is actually a favorable matchup for the Jaguars based on the strengths and weaknesses of each team. 

The Jaguars' rebuilding defense has struggled against the pass, ranking 21st in the league in yards allowed. However, the Jaguars have the No. 1 rushing defense in the league in terms of yards allowed per attempt, giving up just 3.4 yards per carry on the ground. 

This is bad news for the Bills, who rely heavily on their running game while developing Tyrod Taylor at quarterback. The Bills are fifth in the NFL in rushing attempts this season and fourth in rushing yards.

It's tough to call for an upset in this one due to the Jaguars' inconsistencies on offense, but the matchup seems to indicate the potential for a close game. 

Prediction: Bills 24, Jaguars 21

New Orleans Saints at Indianapolis Colts (-4.5)

Jeff Haynes/Associated Press

The Colts have struggled in big games over the past couple of seasons but for the most part, they've avoided playing down to the level of their competition. 

According to ScoresAndOdds.com, the Colts are 11-3 against the spread over the past three seasons when going up against an opponent with a losing record. 

Vegas seems to be underestimating the Colts due to their slow start, as Indianapolis has covered the spread in each of its past two games against the Texans and Patriots. 

With a game under his belt since returning from injury, Andrew Luck should be feeling more confident as he takes the field at home in a favorable matchup against the league's worst defense in terms of yards allowed.

This game has the highest spread of the week at 52 points, according to OddsShark.com, so a shootout is likely. But regardless of the style of game, this appears to be a great matchup for the Colts. 

Prediction: Colts 31, Saints 21