The third round of the 2015 Capital One Cup will see the Premier League's giants enter the fray, with the likes of Chelsea, Manchester United, Arsenal and Liverpool all set to take the field on Wednesday.
Most excitingly, Arsenal will face arch-rivals Tottenham Hotspur at White Hart Lane in a north London derby.
In theory, the others should have an easier time of things but will need to guard against complacency as the Blues travel to Walsall, while United and Liverpool host Ipswich Town and Carlisle United, respectively.
Here are all the third-round fixtures taking place on Wednesday and a closer look at the ties:
|Capital One Cup 2015: Wednesday's Third-Round Fixtures|
|7:45 p.m/2:45 p.m.||Norwich City||vs.||West Brom|
|7:45 p.m/2:45 p.m.||Tottenham Hotspur||vs.||Arsenal|
|7:45 p.m/2:45 p.m.||Crystal Palace||vs.||Charlton Athletic|
|7:45 p.m/2:45 p.m.||Newcastle United||vs.||Sheffield Wednesday|
|7:45 p.m/2:45 p.m.||Walsall||vs.||Chelsea|
|7:45 p.m/2:45 p.m.||MK Dons||vs.||Southampton|
|8 p.m./3 p.m.||Manchester United||vs.||Ipswich Town|
|8 p.m./3 p.m.||Liverpool||vs.||Carlisle United|
There's only one place to start, and that's White Hart Lane.
Arsenal and Spurs' 13 meetings in the League Cup have produced 35 goals and the pair have provided some stunning encounters in the tournament over the years. Squawka Football share the most recent:
Normally, both sides would make a raft of changes at this stage of the competition, but with bragging rights at stake as well as a place in the next round, expect both to field fairly strong teams.
Spurs' season is slowly but surely coming together quite nicely, with the Lilywhites unbeaten since the first match of the campaign and having won their last three in all competitions.
According to James Cambridge of the Express, Tottenham defender Jan Vertonghen believes the club are putting together an exciting young team: "Things are looking very good. We have great young players and a good mix, so there are great things for the team if we can keep working like this. It looks very good for the future."
Arsenal meanwhile will be looking to bounce back from a controversial defeat at the hands of Chelsea.
The Gunners' struggles in the transfer market, opening loss in the Champions League and uninspiring start to the Premier League season have piled some early pressure on Arsene Wenger, who will be as desperate as ever to grab a morale-boosting win over Spurs.
Neither side has been free-scoring this season, but a fiery clash between the two could well produce yet another memorable tie.
Also under pressure is Brendan Rodgers, who is virtually in a no-win situation on Wednesday. Beat Carlisle and the Reds have merely done what is expected. Lose the match and their early struggles will be compounded.
Even so, Rodgers will probably field a number of first-team regulars in a bid to secure a win.
Daniel Sturridge could feature after starting the match with Norwich City on Sunday in order to get more minutes under his belt as he returns from injury.
The Englishman failed to take a good chance to score in the match, but nevertheless Bleacher Report's own Jack Lusby is convinced he will soon find form:
Equally, Danny Ings may start after scoring his first goal for the Reds against the Canaries. The 23-year-old could well end up behind both Sturridge and Christian Benteke in the pecking order, so cup matches will provide a good opportunity for game time.
Nothing is quite clicking at the moment for Liverpool, as Rodgers is still experimenting with team selection and formations so far to little positive effect.
Their opponents are yet to keep a clean sheet this season but are unbeaten in their last five, including three wins, and the League Two outfit upset Queens Park Rangers in the last round, so they will have little fear on Wednesday.
Jabo Ibehre already has 10 goals for the season and will likely provide the Cumbrians' biggest threat.
The Anfield crowd is likely to be tense if the Reds can't settle their nerves with an early goal, so against an uninspiring and potentially nervous Liverpool side Ibehre could fire his side to victory on Wednesday.