Week 10 Fantasy Injury Report and Last Minute Waiver Wire Replacements

Injuries can be the bane of even the best fantasy drafters. We've seen several stars go down this season, and we saw a couple of significant injuries in Week 9.

Los Angeles Rams star Puka Nacua is headed to injured reserve with a neck injury. Arizona Cardinals standout Michael Wilson is done for the year with a neck injury.

While not every injured star is set to miss significant time, the Week 10 injury list extends beyond those two.

Here, we'll dive into the Week 10 injury report, provide rankings for the top remaining point-per-reception (PPR) plays, and highlight sleepers who may still be available on the waiver wire entering the weekend.

Quarterback

AP Photo/Reed Hoffmann

Geno Smith

Top 10

1. Josh Allen, Buffalo Bills
2. Drake Maye, New England Patriots
3. Brock Purdy, San Francisco 49ers
4. Trevor Lawrence, Jacksonville Jaguars
5. Jared Goff, Detroit Lions
6. Joe Burrow, Cincinnati Bengals
7. Dak Prescott, Dallas Cowboys
8. Patrick Mahomes, Kansas City Chiefs
9. Tyler Shough, New Orleans Saints
10. C.J. Stroud, Houston Texans

Injury Report and Waiver-Wire Targets

There are no big injury surprises at quarterback. Kyler Murray and Sam Darnold are both out this week. Presumably, recent addition Kirk Cousins will start for the Minnesota Vikings, while Drew Lock will start for the Seattle Seahawks

New York Jets quarterback Geno Smith had a rough day against the Kansas City Chiefs last week, finishing with just 7.4 fantasy points. However, he should bounce back this week against the Buffalo Bills.

Buffalo has surrendered an average of 16.8 fantasy points to opposing quarterbacks this season. Its defense looked terrific against the Minnesota Vikings on Monday night, but quarterback play has been a massive issue for Minnesota all year.

The Jets are also hopeful that they'll have receiver Garrett Wilson back this week after he missed Week 9 with a concussion.

Smith reached 19 fantasy points in each of his previous two games before facing Kansas City, and he's rostered in only 23 percent of fantasy leagues.

Aaron Rodgers and Deshaun Watson are also viable sleeper options for Week 10.

Running Back

AP Photo/Julio Cortez

Audric Estimé

Top 10

1. Jahmyr Gibbs, Detroit Lions
2. Kenneth Walker III, Kansas City Chiefs
3. Christian McCaffrey, San Francisco 49ers
4. Chuba Hubbard, Carolina Panthers
5. Bijan Robinson, Atlanta Falcons
6. Jaylen Warren, Pittsburgh Steelers
7. James Cook, Buffalo Bills
8. Jonathan Taylor, Indianapolis Colts
9. Kyren Williams, Los Angeles Rams
10. Bhayshul Tuten, Jacksonville Jaguars

Injury Report and Waiver-Wire Targets

Officially, New England Patriots running back Rhamondre Stevenson is questionable, though ESPN's Adam Schefter reported early in the week that he could be sidelined for a "short period of time."

TreVeyon Henderson is out, along with Josh Jacobs. Kenneth Walker III, Travis Etienne Jr., David Montgomery, and Tyjae Spears are listed as questionable.

New Orleans Saints running back Audric Estimé is a prime waiver target this week, and not just because he's coming off a stellar game.

Estimé did rack up 14.7 fantasy points against the Cleveland Browns last Sunday. That's part of the equation. However, he's also likely to see a prominent role moving forward, as the Saints struggled to run the ball regularly before his return. Furthermore, New Orleans is about to face a Carolina Panthers defense that leads the league in fantasy points surrendered to opposing RBs.

Estimé is still only rostered in 47 percent of fantasy leagues.

Emmett Johnson, Kaelon Black, Dylan Sampson, and Mike Washington Jr. are other running backs to consider scooping up this week.

Wide Receiver

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DeMario Douglas

Top 10

1. Jaxon Smith-Njigba, Seattle Seahawks
2. CeeDee Lamb, Dallas Cowboys
3. Amon-Ra St. Brown, Detroit Lions
4. Chris Olave, New Orleans Saints
5. Ja'Marr Chase, Cincinnati Bengals
6. Tee Higgins, Cincinnati Bengals
7. Justin Jefferson, Minnesota Vikings
8. Parker Washington, Jacksonville Jaguars
9. Tetairoa McMillan, Carolina Panthers
10. Nico Collins, Houston Texans

Injury Report and Waiver-Wire Targets

Marvin Harrison Jr., Carnell Tate, Jauan Jennings, and Mike Evans are the most notable receivers who have been ruled out.

A.J. Brown, Amon-Ra St. Brown, Denzel Boston, Jordan Addison, Skyy Moore, Xavier Legette, Omar Cooper Jr., Adonai Mitchell, Garrett Wilson, and Dont'e Thornton Jr. are listed as questionable.

Chris Bell and Andre Iosivas are doubtful.

Brown is still dealing with a knee injury, which makes DeMario Douglas a solid sleeper option for Week 10. He has topped 15 fantasy points in back-to-back weeks and will likely be relied upon heavily this week against the Detroit Lions.

The Lions have been good against the run and not so good against the pass this season. The Patriots, meanwhile, will be without TreVeyon Henderson and Rhamondre Stevenson, which should lead to a very pass-oriented approach this week.

Expect New England's game plan to revolve around Drake Maye's arm, which bodes well for Douglas and the Patriots' other healthy pass-catchers.

Detroit has surrendered the ninth-most fantasy points to opposing receivers this season. Douglas is still available in over half of fantasy leagues.

Tank Dell, Ryan Flournoy, Pat Bryant, and Konata Mumpfield are other wide receivers worth considering this week.

Tight End

AP Photo/Caroline Brehman

Tyler Higbee

Top 10

1. Brock Bowers, Las Vegas Raiders
2. George Kittle, San Francisco 49ers
3. Trey McBride, Arizona Cardinals
4. Tyler Warren, Indianapolis Colts
5. Travis Kelce, Kansas City Chiefs
6. Dalton Kincaid, Buffalo Bills
7. Sam LaPorta, Detroit Lions
8. Hunter Henry, New England Patriots
9. Kyle Pitts, Atlanta Falcons
10. Brenton Strange, Jacksonville Jaguars

Injury Report and Waiver-Wire Targets

Vikings tight end T.J. Hockenson has been ruled out with wrist and chest injuries. Terrance Ferguson, Jake Ferguson, and Mo Alie-Cox are also out.

Rams tight end Tyler Higbee hasn't reached double-digit fantasy points since 5. However, the Rams may turn to him frequently in the coming weeks with both Nacua and Davante Adams sidelined and Ferguson out.

While Higbee only caught one pass last week, he was targeted five times. He should see an even bigger target share this week, and he has a favorable matchup against Arizona.

The Cardinals have surrendered the eighth-most fantasy points to opposing tight ends in 2026. Higbee is rostered in only 13 percent of fantasy leagues.

Darren Waller, Pat Freiermuth, and Darnell Washington are other tight ends to consider this week.

*Fantasy scoring and roster information from FantasyPros.