Week 10 Fantasy Football Rankings, Box Score Projections for Players with Top Matchups

Week 10 got underway on Thursday night, and another 13 matchups remain on the schedule. The action will pick back up on Sunday morning when the New England Patriots battle the Detroit Lions in Munich.

Fantasy managers are undoubtedly searching for the best matchups heading into the rest of the week's schedule. The fantasy playoffs are right around the corner, and simply leaning on star power may not be an option.

The 2026 season has seen injuries aplenty, and the Chicago Bears, Denver Broncos, Philadelphia Eagles, and Tampa Bay Buccaneers have the week off.

Here, you'll find some updated point-per-reception (PPR) rankings, along with stat predictions for our favorite matchups.

Quarterback

AP Photo/Greg M. Cooper

Drake Maye

Rankings

1. Josh Allen, Buffalo Bills
2. Drake Maye, New England Patriots
3. Brock Purdy, San Francisco 49ers
4. Trevor Lawrence, Jacksonville Jaguars
5. Jared Goff, Detroit Lions
6. Joe Burrow, Cincinnati Bengals
7. Dak Prescott, Dallas Cowboys
8. Patrick Mahomes, Kansas City Chiefs
9. Tyler Shough, New Orleans Saints
10. C.J. Stroud, Houston Texans

Matchup to Love: Drake Maye vs. Detroit Lions

Patriots quarterback Drake Maye had a miserable game against the Green Bay Packers in Week 9. He was picked off three times and watched as the Packers built a big early lead. The gap on the scoreboard left the third-year signal-caller abandoning the run.

Maye still topped 21 fantasy points, though, while delivering a high volume of passes in a comeback attempt.

We should see Maye scramble a bit more this week, as New England will be without TreVeyon Henderson and Rhamondre Stevenson. It can use Maye's legs to augment the ground game. He has a lot of upside this week against Detroit.

The Lions boosted their secondary by trading for safety Andre Cisco at the deadline, but they have still surrendered the most fantasy points to opposing quarterbacks in 2026.

Week 10 Projection: 305 passing yards, 2 TDs, 1 INT, 45 rushing yards, 1 rushing TD

Running Back

AP Photo/Scott Kinser

Chuba Hubbard

Rankings

1. Jahmyr Gibbs, Detroit Lions
2. Kenneth Walker III, Kansas City Chiefs
3. Christian McCaffrey, San Francisco 49ers
4. Chuba Hubbard, Carolina Panthers
5. Bijan Robinson, Atlanta Falcons
6. Jaylen Warren, Pittsburgh Steelers
7. James Cook, Buffalo Bills
8. Jonathan Taylor, Indianapolis Colts
9. Kyren Williams, Los Angeles Rams
10. Bhayshul Tuten, Jacksonville Jaguars
11. Javonte Williams, Dallas Cowboys
12. Ollie Gorgon II, Miami Dolphins
13. Derrick Henry, Baltimore Ravens
14. Woody Marks, Houston Texans
15. Breece Hall, New York Jets
16. Audric Estimé, New Orleans Saints
17. Zach Charbonnet, Seattle Seahawks
18. Chase Brown, Cincinnati Bengals
19. Blake Corum, Los Angeles Rams
20. Rico Dowdle, Pittsburgh Steelers

Matchup to Love: Chuba Hubbard at New Orleans Saints

Carolina Panthers running back Chuba Hubbard only saw 16 carries against a stiff Denver Broncos defense in Week 9. However, he caught four of five targets and finished with a solid 13.6 fantasy points.

Hubbard has become one of the most trustworthy backs in fantasy this season, as he's reached double-digit points in every single game. Even in Carolina's blowout loss to the Tampa Bay Buccaneers, he managed to hit 10.0 points despite logging just seven carries.

The Panthers should lean on Hubbard and the ground game much more in this week's NFC South showdown with the New Orleans Saints. Hubbard should shine.

Coming out of the bye, the Saints defense looked much better against the Cleveland Browns last week. However, New Orleans has still surrendered more fantasy points to opposing running backs than any other team.

Week 10 Projection: 109 rushing yards, 3 receptions, 26 receiving yards, 1 TD

Wide Receiver

AP Photo/Nick Wass

Parker Washington

Rankings

1. Jaxon Smith-Njigba, Seattle Seahawks
2. CeeDee Lamb, Dallas Cowboys
3. Amon-Ra St. Brown, Detroit Lions
4. Chris Olave, New Orleans Saints
5. Ja'Marr Chase, Cincinnati Bengals
6. Tee Higgins, Cincinnati Bengals
7. Justin Jefferson, Minnesota Vikings
8. Parker Washington, Jacksonville Jaguars
9. Tetairoa McMillan, Carolina Panthers
10. Nico Collins, Houston Texans
11. Zay Flowers, Baltimore Ravens
12. Drake London, Atlanta Falcons
13. Garrett Wilson, New York Jets
14. Jalen Coker, Carolina Panthers
15. Matthew Golden, Green Bay Packers
16. Christian Watson, Green Bay Packers
17. Jameson Williams, Detroit Lions
18. D.J. Moore, Buffalo Bills
19. DK Metcalf, Pittsburgh Steelers
20. K.C. Concepcion, Cleveland Browns

Matchup to Love: Parker Washington at Tennessee Titans

Like the Panthers, the Jacksonville Jaguars will face a divisional foe this week. Against the Tennessee Titans, that should mean a lot of opportunities for top receiver Parker Washington.

Washington has cemented himself as Trevor Lawrence's top target, and he's rewarded fantasy managers more often than not. He only had two catches last week against the Baltimore Ravens but still found the end zone and delivered 14.1 fantasy points.

Expect Washington to have another strong game, as the Jags look to pour it on against a divisional foe with a lackluster secondary.

The Titans have surrendered more fantasy points to opposing receivers than any other team, and they just traded standout safety Amani Hooker early in the week.

Week 10 Projection: 6 receptions, 98 yards, 1 TD

Tight End

AP Photo/Matt Durisko

Tyler Warren

Rankings

1. Brock Bowers, Las Vegas Raiders
2. George Kittle, San Francisco 49ers
3. Trey McBride, Arizona Cardinals
4. Tyler Warren, Indianapolis Colts
5. Travis Kelce, Kansas City Chiefs
6. Dalton Kincaid, Buffalo Bills
7. Sam LaPorta, Detroit Lions
8. Hunter Henry, New England Patriots
9. T.J. Hockenson, Minnesota Vikings
10. Kyle Pitts, Atlanta Falcons

Matchup to Love: Tyler Warren vs. Miami Dolphins

Following a strong rookie campaign, Indianapolis Colts tight end Tyler Warren has been disappointing on the fantasy front this season. He reached double-digit fantasy points in four of his first five games, then missed a pair of contests, and hasn't hit double digits since.

However, Warren should be back in the fantasy spotlight. The Colts need him to produce against the Miami Dolphins because they're running out of reliable pass-catchers.

Indy traded wideouts Keenan Allen and Josh Downs ahead of Tuesday's deadline. Warren and running back Jonathan Taylor will be the focal points of their offense moving forward.

The Dolphins have surrendered the fourth-most fantasy points to opposing tight ends this season.

Week 10 Projection: 7 receptions, 67 yards, 1 TD

*Fantasy scoring information from FantasyPros.