Latest NFL Odds and Picks Factoring in New Weather Forecasts for Week 10 Schedule

We've reached the midway point in the regular season, and the NFL's trade deadline passed on Tuesday. Now that the trade market is closed, it's time to fully focus on the upcoming Week 10 schedule.

This week's slate will kick off with a Thursday night matchup between the Washington Commanders and New York Giants.

As the second half of the season gets underway, winter is also approaching. Moving forward, weather is increasingly likely to become a factor.

Here, we'll take an early look at the Week 10 slate, the latest odds, and the most accurate forecast information from The Weather Channel to make a few predictions.

NFL Week 10 Schedule

AP Photo/Maria Lysaker

Giants RB Cam Skattebo

Thursday, November 12

Washington Commanders(+1.5) at New York Giants

Schedule: 8:15 p.m. ET on Prime Video

Forecast: Steady Rain, Low of 42°F

Prediction: Commanders

Sunday, November 15

New England Patriots (+2.5) vs. Detroit Lions (in Munich)

Schedule: 9:30 a.m. ET on NFL Network

Forecast: Partly Cloudy, High of 47°F

Prediction: Lions

Kansas City Chiefs (-3.5) at Atlanta Falcons (Retractable Roof)

Schedule: 1 p.m. ET on CBS

Forecast: Partly Cloudy, High of 56°F

Prediction: Chiefs

Houston Texans (-4.5) at Cleveland Browns

Schedule: 1 p.m. ET on Fox

Forecast: Cloudy, High of 45°F

Prediction: Texans

Minnesota Vikings (+3.5) at Green Bay Packers

Schedule: 1 p.m. ET on Fox

Forecast: Partly Cloudy, High of 46°F

Prediction: Vikings

Miami Dolphins (+3.5) at Indianapolis Colts (Retractable Roof)

Schedule: 1 p.m. ET on CBS

Forecast: Cloudy, Winds up to 15MPH, High of 61°F

Prediction: Colts

Carolina Panthers (+2.5) at New Orleans Saints (Dome)

Schedule: 1 p.m. ET on Fox

Forecast: N/A

Prediction: Saints

Buffalo Bills (-7.5) at New York Jets

Schedule: 1 p.m. ET on CBS

Forecast: Mostly Cloudy, High of 62°F

Prediction: Bills

Jacksonville Jaguars (-10.5) at Tennessee Titans

Schedule: 1 p.m. ET on Fox

Forecast: Mostly Cloudy, Winds up to 60MPH, High of 60°F

Prediction: Jaguars

Los Angeles Rams (-9.5) at Arizona Cardinals (Retractable Roof)

Schedule: 4:05 p.m. ET on CBS

Forecast: Mostly Sunny, High of 76°F

Prediction: Rams

Seattle Seahawks (-6.5) at Las Vegas Raiders (Dome)

Schedule: 4:05 p.m. ET on CBS

Forecast: N/A

Prediction: Seahawks

San Francisco 49ers (-4.5) at Dallas Cowboys (Retractable Roof)

Schedule: 4:25 p.m. ET on Fox

Forecast: Rain, Winds up to 15MPH, High of 56

Prediction: 49ers

Pittsburgh Steelers (+3.5) at Cincinnati Bengals

Schedule: 8:20 p.m. ET on NBC

Forecast: Cloudy, Low of 27°F

Prediction: Bengals

Monday, November 16

Los Angeles Chargers (+4.5) at Baltimore Ravens

Schedule: 8:15 p.m. ET on ESPN

Forecast: Cloudy, Low of 36°F

Prediction: Ravens

Bye Week: Chicago Bears, Denver Broncos, Philadelphia Eagles, Tampa Bay Buccaneers

*Odds from FanDuel Sportsbook

Week 10 Preview

AP Photo/Justine Willard

Fernando Mendoza

In addition to the weather—which might be particularly impactful during Thursday night's game—a few situations will make for some unpredictability in Week 10.

Specifically, we're likely to see several games impacted by Tuesday's trade deadline. A look at all of those deals can be found here.

On Sunday morning, the New England Patriots and Detroit Lions will kick off the day's action from Germany. The Lions will have a new safety during the game in trade acquisition Andre Cisco.

The Jacksonville Jaguars will have three new defenders—Jessie Bates III, Jordan Davis, and Davon Godchaux—for their divisional showdown against the Tennessee Titans on Sunday afternoon.

Of course, the biggest changes in Week 10 all involve quarterbacks. The Arizona Cardinals are down to rookie Carson Beck after playing Gardner Minshew on injured reserve. That means the rookie will face the Los Angeles Rams' duo of Myles Garrett and Aaron Donald in his first NFL start.

The Las Vegas Raiders traded Kirk Cousins to the Minnesota Vikings, which will have a two-pronged impact on the week. Cousins should provide an offensive boost for Minnesota against the Green Bay Packers. He won't have a ton of time to prepare, of course, but he's a former Vikings quarterback who knows Kevin O'Connell's system well.

With Cousins out, rookie No. 1 overall pick Fernando Mendoza will make his first career start against the Seattle Seahawks.

The Baltimore Ravens traded for former Cardinals starter Jacoby Brissett a couple of weeks ago, and he should get his first start against the Los Angeles Chargers on Monday night.

The Chargers weren't especially active at the trade deadline, but they do have quarterback questions. Justin Herbert suffered a finger injury in Week 9. While X-rays revealed no broken bones, Herbert may not be close to 100 percent on Monday night.