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A.J. Brown, Lamar Jackson, NFL Injury Statuses and Fantasy Impact for Week 6

Joe Tansey
Oct 16, 2026

Anticipation is growing for injured fantasy football stars to return to their respective lineups.

However, it might be another week until we see A.J. Brown make an impact for the New England Patriots.

Brown practiced this week and is listed as questionable, but a final decision on his Week 6 status won't be made until Saturday.

Lamar Jackson is confirmed to be sidelined for at least one more week. The Baltimore Ravens quarterback was ruled out of the clash with the Cleveland Browns due to his ankle injury.

Below is a look at all of the significant injury news affecting fantasy football lineups in Week 6.

1 p.m. ET Games

Caleb WilliamsQuestionable
Lamar Jackson Out
Jalen Hurts Out
Michael Penix Jr.Off Injury Report, Will Play
Baker Mayfield Out
Saquon BarkleyOut
Will Shipley Out
Breece Hall Out
TreVeyon Henderson Questionable 
Alvin KamaraQuestionable
Kyle Monangai Out 
Quinshon Judkins Questionable
Kenyon SadiqQuestionable
A.J. BrownQuestionable
DeVonta Smith Full Participant In Friday Practice 
Chris Olave Questionable 
DK Metcalf Questionable 
Denzel BostonWill Play Sunday 
Adonai MitchellOut
Jalen Coker Off Injury Report
Ja’Kobi Lane Questionable 

4 p.m. ET Games

Ladd McConkeyFull Participant in Friday Practice
Rashee RiceOut
DJ MooreQuestionable 
Jeremiyah LoveOut

Monday Night

Deebo Samuel Did Not Practice Thursday
Stefon DiggsPracticed Friday 
Jacory Croskey-Merritt Did Not Practice Friday 

Decision To Be Made On A.J. Brown On Saturday

Patriots head coach Mike Vrabel said a final decision on A.J. Brown's Week 6 status won't be made until Saturday.

"We won't make that decision until tomorrow. We want to see how he responds to practice today and go from there," Vrabel said in his Friday press conference.

Brown has been on the injured reserve since he suffered an ankle injury in Week 1.

He has participated in practice this week, but the Patriots wanted to wait to see how Brown responded to his time on the practice field.

The Patriots might not need Brown on Sunday against the New York Jets, especially if other wide receivers step up in the same way they did in the Week 5 blowout win over the Las Vegas Raiders.

Thursday's trip to Chicago may also play a factor in the decision on Brown. A quick turnaround time between games might affect Brown's availability for the showdown with the Chicago Bears.

Demario Douglas is the Patriots wide receiver to pick up if Brown is unable to go. He had a pair of touchdowns last week against the Raiders.

Hunter Henry, who had three receptions for 44 yards and a score in Week 5, is worth a waiver-wire pickup for the FLEX spot on your roster, or if you're in need of a tight end.

Sunday's London game between the Houston Texans and Jacksonville Jaguars might be the spot to add replacements for Brown. Houston and Jacksonville both rank in the top three in receiving yards allowed to wide receivers.

Houston's Xavier Hutchinson and Jacksonville's Josh Cameron are two deep sleepers to consider if you think the game opens up for both passing games.

Lamar Jackson Out For Another Week

Lamar Jackson's ankle injury is once again keeping him out of a game.

The Ravens will go with Tyler Huntley at quarterback for the AFC North battle with the Browns.

Huntley threw for 201 yards in the Week 5 overtime win over the Atlanta Falcons. Rashod Bateman led the Ravens with 62 receiving yards.

Zay Flowers and Mark Andrews received their fair share of targets, but no pass-catcher exploded for a massive day with Huntley at the helm.

However, Josh Cuevas' two catches for 26 yards stood out. He might be a good deep sleeper at tight end if you need a player at that position due to injuries and the four teams on bye in Week 6.

C.J. Stroud, Brock Purdy and Bryce Young all face teams in the top 10 of most passing yards conceded, so they are all good options if they are available.

Cam Ward might be worth a look in place of Jackson on fantasy rosters for Week 6. The Tennessee Titans face an Indianapolis Colts defense that have allowed the fifth-most passing yards in the NFL.