San Francisco 49ers' 2026 NFL Draft Picks and Needs

Picks: Nos. 27, 58, 127, 133, 138, 139

Top Needs: Edge, DB, OL

The San Francisco 49ers made do with an injury-plagued defense in 2025, but they could use significant improvements on that side of the ball. Nick Bosa may or may not be at 100 percent after last year's torn ACL. Former defensive coordinator Robert Saleh won't be around to patch things together.

San Francisco especially needs help with its 25th-ranked pass defense. Whether or not Bosa is healthy, the 49ers need another edge-defender—2025 first-round pick Mykel Williams is also recovering from a torn ACL. Cornerback and safety are also defensive needs.

Offensively, San Francisco could use depth at guard and insurance at tackle, though Trent Williams' two-year extension makes tackle a bit less of a priority.

Expect prospects such as Oregon safety Dillon Thieneman, Clemson cornerback Avieon Terrell, and Texas A&M edge-rusher Cashius Howell to interest the 49ers in Round 1.

The list of prospects GM John Lynch is likely to consider on Day 2 includes Georgia Tech lineman Keylan Rutledge, South Carolina safety Jalon Kilgore, and South Carolina corner Brandon Cisse.