Fantasy Football Week 10 Rankings, Projections and Waiver-Wire Tips

Week 10 in the 2025 NFL season brings with it several favorable match-ups for some of the top fantasy performers in the league.

Indianapolis Colts running back Jonathan Taylor, Los Angeles Rams wide receiver Puka Nacua, and Arizona Cardinals tight end Trey McBride are all poised for big days, entering the week as indisputable must-starts.

Where do they rank among their peers in the top 20 FLEX options, and who are two young, potential breakout waiver wire additions that deserve managers' attention?

Find out in this preview of the fantasy week to come.

All fantasy stats via FantasyPros.com unless otherwise noted.

Week 10 FLEX Rankings

AP Photo/Gregory Bull

The top 20 players in fantasy for Week 10 are:

Puka Nacua, WR, Los Angeles Rams at San Francisco 49ers

Jahmyr Gibbs, RB, Detroit Lions at Washington Commanders

Jonathan Taylor, RB, Indianapolis Colts vs. Atlanta Falcons

Christian McCaffrey, RB, San Francisco 49ers vs. Los Angeles Rams

Jaxson Smith-Njigba, WR, Seattle Seahawks vs. Arizona Cardinals

Bijan Robinson, RB, Atlanta Falcons at Indianapolis Colts

Justin Jefferson, WR, Minnesota Vikings vs. Baltimore Ravens

James Cook, RB, Buffalo Bills at Miami Dolphins

Amon-Ra St. Brown, WR, Detroit Lions at Washington Commanders

Tyler Warren, TE, Indianapolis Colts vs. Atlanta Falcons

Trey McBride, TE, Arizona Cardinals at Seattle Seahawks

De'Von Achane, RB, Miami Dolphins vs. Buffalo Bills

Saquon Barkley, RB, Philadelphia Eagles at Green Bay Packers

Kyren Williams, RB, Los Angeles Rams at San Francisco 49ers

Nico Collins, WR, Houston Texans vs. Jacksonville Jaguars

Drake London, WR, Atlanta Falcons at Indianapolis Colts

Derrick Henry, RB, Baltimore Ravens at Minnesota Vikings

Emeka Egbuka, WR, Tampa Bay Buccaneers vs. New England Patriots

Kimani Vidal, RB, Los Angeles Chargers vs. Pittsburgh Steelers

Josh Jacobs, RB, Green Bay Packers vs. Philadelphia Eagles

Waiver Wire: Harold Fannin Jr., TE, Cleveland Browns

AP Photo

The Cleveland Browns are far from an offensive juggernaut but one bright spot among the dreariness has been the play of tight end Harold Fanning Jr.

The Bowling Green product has delivered four double-digit, PPR fantasy performances in eight weeks, including a two-touchdown game against the New England Patriots Sunday in Foxboro.

He is averaging over six targets a game this season and that is with David Njoku in the lineup.

With the possibility that the Pro Bowl tight end is traded before Tuesday's deadline, there is potential for Fannin to become the undisputed No. 1 at his position.

He has been a top-10 fantasy performer at the tight end position in two of the last three weeks, and that is a trend that should continue as he builds chemistry with quarterback Dillon Gabriel.

Against a Jets team giving up the 13th-most points to opposing tight ends, he could be in store for a big Week 10.

Projections: Six catches, 50 yards, TD

Isaiah Davis, RB, New York Jets

AP Photo

With the buzz surrounding Breece Hall and his candidacy for a trade at Tuesday's deadline, attention should be paid to Jets running back Isaiah Davis.

The second-year player out of South Dakota State has carried 17 times for 109 yards, an average of 6.4 yards per carry. His speed and explosiveness should have fans and fantasy managers alike excited about the impact the 23-year-old could have on the future of the Jets' offense.

Even if Hall stays, Davis' best has been too great to ignore, likely opening the door for a dual running back setup that would garner him opportunities to become a bigger factor in fantasy football.

While there may be hesitancy related to his unproven track record, Davis is one or two opportunities away from jumping off the screen and into fantasy lineups and there is no reason why every manager should not make sure it is there's he is starring in.

The Browns defense is a tough sell as they allow the fewest points to opposing running backs, but Davis' speed is such a tool that it could prove problematic even for a stingy defense.

If nothing else, he is a grab and stash for managers in deeper leagues.

Projections: Nine carries, 60 yards, three receptions, 24 yards