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Week 4 Fantasy Football Cheat Sheet for Deep Sleepers to Grab on Waiver Wire

Kristopher KnoxSep 24, 2025

In what seems to be a yearly occurrence, early NFL injuries have once again impacted the fantasy landscape. More stars were lost to season-ending injuries in Week 3, including Nick Bosa, Najee Harris and James Conner.

They join an already star-studded list of injured players that includes Joe Burrow, George Kittle, Khalil Mack and Aaron Jones.

Bye weeks are quickly approaching too—they'll begin in Week 5—which will spread many fantasy rosters even thinner than they already are. The time to search for potential replacements on the waiver wire is now.

Before we jump into this week's top waiver targets, let's review the top flex plays for points-per-reception (PPR) formats.

Week 4 Flex Top 40

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Cardinals 49ers Football
49ers RB Christian McCaffrey
  1. Christian McCaffrey, RB, San Francisco 49ers
  2. Puka Nacua, WR, Los Angeles Rams
  3. Jonathan Taylor, RB, Indianapolis Colts
  4. James Cook, RB, Buffalo Bills
  5. Bijan Robinson, RB, Atlanta Falcons
  6. Saquon Barkley, RB, Philadelphia Eagles
  7. Jaxon Smith-Njigba, WR, Seattle Seahawks
  8. De'Von Achane, RB, Miami Dolphins
  9. Malik Nabers, WR, New York Giants
  10. Josh Jacobs, RB, Green Bay Packers
  11. Justin Jefferson, WR, Minnesota Vikings
  12. Jahmyr Gibbs, RB, Detroit Lions
  13. Amon-Ra St. Brown, WR, Detroit Lions
  14. Nico Collins, WR, Houston Texans
  15. Bucky Irving, RB, Tampa Bay Buccaneers
  16. Derrick Henry, RB, Baltimore Ravens
  17. Garrett Wilson, WR, New York Jets
  18. Ja'Marr Chase, WR, Cincinnati Bengals
  19. Jordan Mason, RB, Minnesota Vikings
  20. Omarion Hampton, RB, Los Angeles Chargers
  21. Davante Adams, WR, Los Angeles Rams
  22. Drake London, WR, Atlanta Falcons
  23. Rome Odunze, WR, Chicago Bears
  24. Trey McBride, TE, Arizona Cardinals
  25. Kyren Williams, RB, Los Angeles Rams
  26. Kenneth Walker III, RB, Seattle Seahawks
  27. A.J. Brown, WR, Philadelphia Eagles
  28. Zay Flowers, WR, Baltimore Ravens
  29. Brock Bowers, TE, Las Vegas Raiders
  30. Emeka Egbuka, WR, Tampa Bay Buccaneers
  31. Tetairoa McMillan, WR, Carolina Panthers
  32. Breece Hall, RB, New York Jets
  33. Ashton Jeanty, RB, Las Vegas Raiders
  34. Javonte Williams, RB, Dallas Cowboys
  35. George Pickens, WR, Dallas Cowboys
  36. Ladd McConkey, WR, Los Angeles Chargers
  37. Chuba Hubbard, RB, Carolina Panthers
  38. Trey Benson, RB, Arizona Cardinals
  39. Jakobi Meyers, WR, Las Vegas Raiders
  40. Keenan Allen, WR, Los Angeles Chargers

*PPR Scoring

Sleeper Cheat Sheet, Week 4

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Saints Seahawks Football
Seahawks QB Sam Darnold

Quarterback

  1. Sam Darnold, Seattle Seahawks
  2. Matthew Stafford, Los Angeles Rams
  3. Tua Tagovailoa, Miami Dolphins
  4. Geno Smith, Las Vegas Raiders
  5. Carson Wentz, Minnesota Vikings

Running Back

  1. Ollie Gordon II, Miami Dolphins
  2. Braelon Allen, New York Jets
  3. Chris Rodriguez Jr., Washington Commanders
  4. Blake Corum, Los Angeles Rams
  5. Jeremy McNichols, Washington Commanders

Wide Receiver

  1. Elic Ayomanor, Tennessee Titans
  2. Darnell Mooney, Atlanta Falcons
  3. Tre Tucker, Las Vegas Raiders
  4. Troy Franklin, Denver Broncos
  5. Luther Burden III, Chicago Bears

Tight End

  1. Harold Fannin Jr., Cleveland Browns
  2. Brenston Strange, Jacksonville Jaguars
  3. Chigoziem Okonkwo, Tennessee Titans
  4. Dalton Schultz, Houston Texans
  5. Mason Taylor, New York Jets

Deep Sleeper: Tory Horton, WR, Seattle Seahawks

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Saints Seahawks Football

Seattle Seahawks rookie receiver Tory Horton hasn't reached star status just yet. However, he's beginning to carve out a prominent role in Seattle's offense. After receiving zero targets in Week 1, Horton has been targeted four times in each of the past two games, finishing both with three receptions, 32 yards and a touchdown.

Horton also scored on a punt return in Week 3, which could earn him increased opportunities moving forward. Offensive coordinator Klint Kubiak should look to get the football in his hands.

Despite being on a short week and on the road, Horton has a solid matchup in Week 4. He'll visit the Arizona Cardinals, who have surrendered the 12th-most fantasy points to opposing wide receivers this season.

Horton is still available in over 90 percent of Yahoo and ESPN leagues.

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Deep Sleeper: Woody Marks, RB, Houston Texans

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Buccaneers Texans Football

Finding quality running backs on the waiver wire this year has been difficult when injuries haven't been directly involved—Cardinals back Trey Benson, for example, jumped into starter status when Conner went down for the year.

However, managers should consider making an early play for Houston Texans rookie back Woody Marks. While Nick Chubb remains Houston's starter, Marks could take over as the lead back in the coming weeks.

Marks is the more explosive of the two runners at this point in their careers, and Houston simply isn't opening up many running lanes. After seeing just seven touches in the first two weeks combined, Marks saw seven in Week 3.

While Marks is still firmly in deep-sleeper territory, that will quickly change if he has a good outing against the Tennessee Titans in Week 4. Tennessee, by the way, has allowed the third-most fantasy points to opposing RBs.

Marks is available in over 80 percent of ESPN and Yahoo leagues.

*Fantasy scoring and roster information from FantasayPros.

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