Christian McCaffrey, Tyreek Hill, NFL Injury Statuses and Fantasy Impact for Week 1

Christian McCaffrey's injury status is once again being carefully watched by fantasy football players.

The San Francisco 49ers running back is officially listed as questionable for the Week 1 matchup with the Seattle Seahawks.

McCaffrey did not practice on Friday due to a calf issue. He's dealt with calf injuries in the past.

Fantasy football players did receive some good news, though, as Tyreek Hill has no limitations for the Miami Dolphins' Week 1 clash with the Indianapolis Colts.

Below is a look at all of the notable injury news that will affect fantasy football matchups in Week 1.

• Christian McCaffrey, RB, SF: Questionable (calf), per ESPN's Adam Schefter.
• Tyreek Hill, WR, MIA: No injury designation (oblique/calf), per ESPN's Marcel Louis-Jacques
• Matthew Stafford, QB, LAR: "Good to go" (back), per NFL Network's Ian Rapoport.
• Malik Nabers, WR, NYG: Off injury report (back), per Rapoport.
• De'Von Achane, RB, MIA: No injury designation (calf), per ESPN's Marcel Louis-Jacques
• Jaylen Wright, RB, MIA: Out (knee), per ESPN's Marcel Louis-Jacques
• Roschon Johnson, RB, CHI: Did not practice Friday (foot), per team injury report.
• Chris Godwin, WR, TB: Out (leg), per ESPN's Jenna Laine.
• Darnell Mooney, WR, ATL: Questionable (shoulder), per NFL Network's Tom Pelissero.
• Jaylen Reed, WR, GB: Questionable (foot), per team injury report.
• Christian Kirk, WR, HOU: Out (hamstring), per Underdog.
• Isaiah Likely, TE, BAL: Out (foot), per NFL
• Darren Waller, TE, MIA: Out (hip), per team injury report.

Christian McCaffrey Officially Questionable

ESPN's Adam Schefter reported that Christian McCaffrey did not practice on Friday and is listed as questionable for the 49ers' season opener.

McCaffrey was a limited participant in Thursday's practice due to a calf issue. That was the news that sent alarm bells through the fantasy football community.

There's reason to be worried about how McCaffrey will affect fantasy teams in 2025 because he only played in four games last season.

McCaffrey has dealt with calf issues in the past, which is why the news of him missing practice on Friday is so concerning.

Brian Robinson, who was recently acquired from the Washington Commanders, is listed as the 49ers backup running back. He is worth looking at on the waiver wire in case McCaffrey is unable to play on Sunday.

Denver's JK Dobbins or RJ Harvey, Minnesota's Jordan Mason and Jacksonville's Tank Bigsby are among the potential waiver-wire pickups at running back outside of the 49ers roster.

Tyreek Hill Has No Injury Designation

Tyreek Hill is cleared and ready to go for the Miami Dolphins.

The star wide receiver was a full participant in practice on Friday and does not have an injury designation for the season opener against the Indianapolis Colts, per ESPN's Marcel Louis-Jacques.

Hill had been a limited participant in practice on Wednesday and Thursday due to oblique and calf issues.

Hill's status is a welcome sight not just for fantasy players with him on the roster, but for those who drafted Tua Tagovailoa as well.

Hill and Jaylen Waddle should receive most of the targets inside the Miami passing game with tight end Darren Waller ruled out.

Miami's offense will be at near full strength on Sunday. Running back De'Von Achane was also a full participant in practice on Friday.

The Dolphins are going up against a Colts defense that gave up the seventh-most passing yards in 2024. They might be able to exploit some weaknesses in the secondary to start the season off on the right for themselves and fantasy players relying on their production.