NFL Betting Odds For Every Regular-Season Game Revealed After 2025 Schedule Release

The start of the 2025 NFL regular season is still about four months away, but you can already bet on every single game if you are so inclined.

Following Wednesday's full schedule release, DraftKings Sportsbook revealed its betting lines and spreads for the entirety of the season.

The NFL season will begin with the defending champion Philadelphia Eagles facing their divisional rivals, the Dallas Cowboys. The Eagles will open as seven-point favorites.

Other notable matchups that week include an AFC West showdown between the defending AFC champion Kansas City Chiefs and Los Angeles Chargers (+3), the Tampa Bay Buccaneers and Atlanta Falcons (+2.5) and the Baltimore Ravens and Buffalo Bills (-1.5) contesting a rematch of last year's Divisional Round classic.

The Eagles and Chiefs will face off in Week 2 in a Super Bowl rematch, with Kansas City currently 1.5-point favorites at Arrowhead Stadium. And when the Chiefs and Bills hold their now-annual matchup in the regular season, it will be Buffalo who is 2.5-point favorites at home.

If you were wondering whether your favorite team might be favored against their biggest rival, don't fear—the answer is already here. Four months away from the start of the season, before training camp or the preseason or even the end of the NBA and NHL playoffs.