Seattle Seahawks vs. San Francisco 49ers Betting Odds, Analysis, NFL Pick

NFL bettors can give thanks for a blockbuster NFC West matchup on Thanksgiving night when the Seattle Seahawks visit the San Francisco 49ers in the next chapter of their epic rivalry.

The Seahawks have covered the spread in the last six meetings with the 49ers, who are 15-1-1 straight up in their past 17 home games against divisional opponents.

Point spread: The 49ers opened as one-point favorites; the total was 40 early in the week, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)

NFL pick, via Odds Shark computer: 25.4-20.5 Seahawks

Why the Seahawks can cover the spread

Seattle is the defending NFC West, conference and Super Bowl champion playing its biggest rival in prime time, which alone is enough for some to back the team in this spot. However, the Seahawks have also played well as road underdogs over the last few years with a 9-3-1 mark against the spread in their past 14 games under that scenario.

They do not need any extra motivation to play San Francisco here and know what is at stake, especially after beating the Arizona Cardinals 19-3 last week as 7.5-point favorites. Despite Arizona’s hot 9-2 start, the division is up for grabs, and Seattle has the inside track based on past experience and the mental edge possessed over its opponents.

The 49ers have not been great at home lately and ride a 1-6 ATS home streak into this game, per the Week 13 NFL trends sheet.

Why the 49ers can cover the spread

Like the Seahawks, the 49ers know they cannot afford to lose this game, especially at home if they have any hopes of winning the NFC West. They need to forget the final result of last year’s NFC Championship Game loss at Seattle and focus instead on what they can change now, getting revenge and making a statement in the process.

San Francisco has underachieved in the first year playing at new Levi’s Stadium, and the team may have been caught looking ahead to this game last week in a 17-13 victory against the Washington Redskins as 9.5-point favorites.

There is no more looking ahead and past this week’s foe, and the 49ers should be more than ready for them.

Smart Pick

The line on this game is right where it should be considering the Seahawks have struggled a bit on the road this year while San Francisco does not currently possess a strong home field.

What bettors should know about these two teams when they play each other if they do not already is that points are at a premium. The total has gone under in five of the past six meetings, including each of the previous three.

The under is also 5-2 in Seattle’s last seven road games against NFC West opponents and 3-0 in the past three home matchups with divisional foes for the 49ers. No matter who wins this one, it will be a low-scoring affair with the combined score dipping below the total again.

Betting Trends

Seattle is 2-5 ATS in its last seven games

San Francisco is 1-6 ATS in its last seven games at home

Note: All spread and odds data powered by Odds Shark—follow us on Twitter for injury updates and line-move updates.