College Football Odds: Opening Week 10 Betting Lines and Totals

The Florida State Seminoles will be gunning for their 24th consecutive straight-up win when they take on their newest ACC conference rivals, the Louisville Cardinals, as early 8.5-point favorites at sportsbooks monitored by Odds Shark.

No. 2 Florida State is just one of three FBS teams that remain undefeated this season. No. 1 Mississippi State improved to 7-0 this weekend to stay atop the AP Top 25 rankings, while No. 23 Marshall enters Week 10 with a perfect 8-0 record.

The 6-2 Cardinals are coming off a 30-18 win over North Carolina State, failing to cover as 19-point favorites. The victory moved Louisville to 4-0 SU at home, 2-2 against the spread, ahead of Thursday night’s Seminoles vs. Cardinals betting matchup at Papa John’s Cardinal Stadium.

Mississippi State takes on the Arkansas Razorbacks on Saturday night in an SEC matchup, with the Bulldogs pegged as early 14-point home favorites. The Bulldogs struggled to put away the tough Kentucky Wildcats last weekend, topping the Wildcats in a 45-31 slugfest. However, they disappointed bettors by failing to cover as 14.5-point favorites, dropping to 5-2 ATS on the season.

The Razorbacks are 0-4 against conference opponents this season but were dominant in a 45-17 win over UAB as 24.5-point favorites last weekend. The Razorbacks have produced mixed results in recent visits to Davis Wade, winning five of their last seven SU but covering in just one of their last six.

No. 4 Auburn will be looking to match No. 3 Alabama’s 7-1 record when they take on No. 7 Ole Miss as early three-point road underdogs at sportsbooks monitored by Odds Shark.

While the Tigers are an impressive 15-2 SU in their last 17, they have been a shaky bet this season, going 1-4 ATS in their last five and 3-4 ATS overall.

The 7-1 Rebels tumbled from third spot in the national rankings this week after a shocking 10-7 loss to LSU as 3.5-point favorites. The loss ended Mississippi’s eight-game winning streak, SU and ATS. The Rebels are just 2-7 SU in their last nine home dates against Auburn, 3-6 ATS.

In other Week 10 college football betting action, No. 21 East Carolina is a seven-point favorite over Temple, while No. 24 Duke is an early 2.5-point road underdog against Pittsburgh, and No. 6 Notre Dame is a 13.5-point road favorite against the Navy Midshipmen.