NFL Odds: Week 4 Opening Lines, NFC East Clash Thursday

Washington is a favorite in early NFL odds for this week as it gets set to take on its NFC East rival from New York on Thursday Night Football in one of the highlight games of Week 4.

With Kirk Cousins looking comfortable at the helm in place of the injured Robert Griffin III, Washington has exploded for 75 points combined in its last two outings. There was a 41-10 thumping of the Jacksonville Jaguars and a 37-34 loss to the Philadelphia Eagles in which Cousins threw for an incredible 427 yards and three scores.

However, 1-2 Washington has struggled against the 1-2 Giants, winning just two of its last eight at home straight up. But Washington has been a solid bet with a 5-2 record against the spread in its last seven against New York.

Philadelphia will be looking to improve to a perfect 4-0 when it takes on the San Francisco 49ers as five-point road underdogs at sportsbooks monitored by Odds Shark.

The Eagles' fast start has boosted their Super Bowl odds, which sat at a distant 40-1 prior to Week 1 but are currently among the favorites at 10-1.

Sunday afternoon’s Eagles vs. 49ers matchup at Levi’s Stadium is critical for the 'Niners, whose 1-2 start has put them in a hole in the tough NFC West. However, the 49ers maintain strong 16-1 Super Bowl odds at the sportsbooks.

The 2-1 Buffalo Bills will look to bounce back from a disappointing Week 3 loss to San Diego when they take on the Houston Texans as three-point road underdogs.

The Bills face a 2-1 Texans team that has impressed early on, with their defense holding opponents to less than 17 points per game.

While the Bills offense sputtered last week against the Chargers, the unit has shown flashes of brilliance, with quarterback E.J. Manuel connecting with dynamic rookie wide receiver Sammy Watkins eight times for 117 yards and a touchdown in their 29-10 Week 2 win over Miami.

In other NFL Week 4 betting action, the 1-2 Indianapolis Colts will look to build on a 44-17 rout of Jacksonville last week as seven-point favorites over the Tennessee Titans. Meanwhile, the Chargers will get their chance this week to beat up on the Jags, pegged as 13.5-point home favorites over Jacksonville.

The NFL will also play its first game in London this season, as the 1-2 Dolphins will take on the 0-3 Oakland Raiders as 4.5-point road favorites at Wembley Stadium.

Stats and odds courtesy of Odds Shark and NFLOdds.ca.