NFL Picks Week 15: Latest Spread Info and Upset Predictions

Week 15 in the NFL doesn't offer a ton of exciting matchups outside of the prime-time games, but there are certainly quite a few games that could see the underdog make the game close or even pull off a win.

With just three weeks remaining in the regular season, bettors are looking to line their pockets with huge upsets before the playoffs begin. While some games might not be the best for the eyes, here are the games where the underdog will pull off the upset.

Away	Home	Spread	Pick ATS
San Diego Chargers	Denver Broncos	DEN -10.5	Chargers
Buffalo Bills	Jacksonville Jaguars	BUF -2	Jaguars
Chicago Bears	Cleveland Browns	CLE -2	Bears
Houston Texans	Indianapolis Colts	IND -6	Colts
New England Patriots	Miami Dolphins	NE -2.5	Dolphins
Philadelphia Eagles	Minnesota Vikings	PHI -4.5	Eagles
Seattle Seahawks	New York Giants	SEA -7	Seahawks
San Francisco 49ers	Tampa Bay Buccaneers	SF -5.5	49ers
Washington Redskins	Atlanta Falcons	ATL -6	Falcons
New York Jets	Carolina Panthers	CAR -11	Panthers
Kansas City Chiefs	Oakland Raiders	KC -4	Chiefs
Green Bay Packers	Dallas Cowboys	PK	Cowboys
New Orleans Saints	St. Louis Rams	NO -5.5	Saints
Arizona Cardinals	Tennessee Titans	ARI -3	Cardinals
Cincinnati Bengals	Pittsburgh Steelers	CIN -3	Bengals
Baltimore Ravens	Detroit Lions	DET -6	Ravens

Jacksonville Jaguars (+2 vs. Buffalo Bills)

The Jaguars have won four out of their last five after starting the season off 0-8. While NFL fans might not be paying attention to this team anymore, it is actually playing pretty well as of late.

The Bills rushing defense is putrid. Jacksonville's Maurice Jones-Drew has put up three straight weeks of over 75 yards and posted a 100-yard rushing game last week. This is a matchup made in heaven for Jacksonville.

While the Bills are very capable of beating any opponent by stopping the pass and getting their own running game going, they just got shut down by a Tampa Bay Buccaneers team that is very similar to the Jaguars and lost by 21 points.

Prediction: Jaguars 24, Bills 13

Chicago Bears (+2 at Cleveland Browns)

The Bears have been absolutely awful on defense, but their offense has been good enough to win games. While they've gone 3-2 over their last five games, the Bears will have Jay Cutler back behind center against a top-10 passing defense.

If Matt Forte can get the offense started against a Browns defense that only allows 98 yards per game—ranking fourth in the NFL—and take some of the weight off Cutler's shoulders, expect the Bears to roll. But much of this prediction is dependent on one of the two facets of this Chicago offense getting going.

The Browns proved last week that they can contend with any team as they came within two minutes of defeating a very good New England Patriots team. But returning home to face a Chicago team that is finally fully healthy is not exactly a good matchup for this team.

Prediction: Bears 27, Browns 21

Miami Dolphins (+2.5 vs. New England Patriots)

Here's the biggest upset prediction of the weekend. The Patriots are a top-five team in the NFL, but with the loss of Rob Gronkowski for the season, the makeup of this team will have to change once again against a tough Miami Dolphins team on the road.

Aside from the loss of Gronkowski, it appears Aaron Dobson, another starting receiver for the Patriots, is still missing practice after being inactive in Week 14, according to Mike Reiss of ESPN:

Ryan Tannehill has been playing very well as of late for the Dolphins. Miami has gone 3-1 in its last four games thanks to Tannehill averaging over 277 yards per game along with seven touchdowns. The only issue for the second-year starter will be cutting down on the four interceptions he's thrown over that stretch.

Tannehill will be facing off with Tom Brady, who has certainly proven that he can get the job done with just about any group around him. In just seven starts on the season, though, Gronkowski caught 39 passes on 67 targets from Brady for 592 yards and four touchdowns.

The Patriots have lost the physicality and size of Gronkowski and will have to replace it with young receivers like Kenbrell Thompkins and slot receivers like Julian Edelman and Danny Amendola. That won't be enough against Miami.

Prediction: Dolphins 28, Patriots 24