St. Louis Rams vs. San Francisco 49ers: Spread Analysis and Pick Prediction

The Rams have covered five of their last seven games against the 49ers, but they've also been shut out in two of their last four trips to the Bay Area.

Point spread: 49ers opened as 11.5-point favorites; the total was 42. (Line updates and matchup report)

Odds Shark computer prediction: 27.2-21.7 49ers

Why the Rams can cover the spread

St. Louis has won two in a row and four of its last seven games, while it has covered three of its last four. The Rams, undoubtedly under the guidance of coach Jeff Fisher, have outscored their opponents by an average of 38-15.5 in those four wins, including a 38-8 road win over the Colts.

They also bring a 5-2 ATS streak in games played at San Francisco.

Why the 49ers can cover the spread

After two trying road trips—to New Orleans and Washington D.C.—the past two weeks, the Niners will be glad to be at home over the next two weeks and three of the next four. San Francisco can't afford any letdowns with the Arizona Cardinals in the mix for a wild-card berth.

Smart Pick

The Rams are the play here, as they're exuding confidence right now and will come in fired up knowing they have a chance to gain some ground on San Francisco in the NFC West. Plus, the Niners could get caught looking ahead to the Seahawks next week.

Trends:

• St. Louis is 5-2 ATS in its last seven games when playing San Francisco
  San Francisco is 15-8 ATS in its last 23 games at home
  Rams have been shut out two of past four trips here

Note: All spread and odds data powered by Odds Shark—follow them on Twitter for injury updates and line move updates.