San Francisco 49ers vs. Jacksonville Jaguars: Spread Analysis, Pick Prediction

The NFL is back in London, and the 49ers bring winning runs of 6-1 SU and ATS as the road chalk into this game. Travel can be taken into consideration and coupled with the fact the Niners have stayed under in eight of their last 11 before a bye week.

Point spread: The game has remained off the board through Wednesday. (Line updates and Matchup report)

Computer Prediction: 25.5-3.0 49ers

Why the 49ers can cover the spread

Since losing two in a row, the defending NFC champions are playing the winless Jaguars after winning four straight in dominating fashion. San Francisco's four-game win streak has come by way of a combined final of 132-51. The 49ers climbed from 9th to a tie for 7th in the league in points allowed, with 19.3 points per game.

Why the Jaguars can cover the spread

With this game in London, you can add an extra five hours to the Niners' travel time—both to and from—and so once this game is in hand, you may see Frisco take its foot off the gas pedal and coast to a victory. Add a change of scenery, where both teams will be cheered—not jeered—and the Jags may respond.

Smart Pick

Who are we kidding here? The 49ers are playing dominating football and should absolutely annihilate Jacksonville. Don't let the "low line" fool you, San Francisco should win this game going away, as it's found a groove and a trip across the pond won't disrupt that. The Jaguars have lost every game this season by double digits. This one might reach triple digits!

Trends:

The UNDER is 8-3 in the 49ers’ past 11 seasons before a bye week.

All three prior meetings played UNDER the total.

Note: All spread and odds data powered by Odds Shark - follow them on Twitter for injury updates and line move updates.