NFL Opening Odds for Week 6: Broncos' Historic Point Spread vs. Jaguars

The biggest point spread in NFL history is the highlight of Week 6 NFL betting lines. Three other games feature double-digit spreads, according to OddsShark.com.

The 49ers, Seahawks and Chiefs—among the favorites in Super Bowl odds—are all favored by 10 or more points, but it's a point-spread pittance compared with the -28 line favoring the Denver Broncos over the Jacksonville Jaguars.

No other point spread in the past 40 years has been higher than 24 points (Patriots vs Eagles back in 2007).

While there are huge favorites, there are also three games which Vegas and online sportsbooks have declared toss-ups. Philly at Tampa, Indy at San Diego and Pittsburgh vs. the Jets all opened at even odds.

The week begins Thursday with the 0-5 Giants as big underdogs at Chicago. New York has won four straight at Soldier Field, but things have gotten so bad for Big Blue that even strippers are complaining in a city club.

Check out the opening Week 6 NFL lines and trends courtesy of OddsShark.com.

NY Giants +9.5 at Chicago -9.5, Total 47 - Matchup Report

Trends: The total has gone UNDER in 6 of the NY Giants last 7 games on the road.
The total has gone OVER in 6 of Chicago's last 7 games.

Detroit -2.5 at Cleveland +2.5, Total 45 - Matchup Report

Trends: The total has gone UNDER in 4 of Detroit's last 5 games on the road.
The total has gone UNDER in 12 of Cleveland's last 16 games at home.

Philadelphia PK at Tampa Bay PK, Total 46 - Matchup Report

Trends: The total has gone OVER in 7 of Philadelphia's last 8 games. 
The total has gone UNDER in 5 of Tampa Bay's last 5 games.

St. Louis +8.5 at Houston -8.5, Total 43 - Matchup Report

Trends: The total has gone OVER in 4 of St. Louis's last 5 games. 
Houston is 6-2 SU in its last 8 games at home.

Oakland +10 at Kansas City -10, Total 40.5 - Matchup Report

Trends: Oakland is 5-0 SU in its last 5 games when playing on the road against Kansas City.
Kansas City is 5-0 SU in its last 5 games.

Green Bay -2.5 at Baltimore +2.5, Total 48 - Matchup Report

Trends: The total has gone OVER in 4 of Green Bay's last 5 games. 
Baltimore is 20-2 SU in its last 22 games at home.

Carolina +1 at Minnesota -1, Total 43.5 - Matchup Report

Trends: The total has gone UNDER in 6 of Carolina's last 7 games when playing Minnesota.
The total has gone UNDER in 6 of Minnesota's last 7 games when playing Carolina.

Cincinnati -8.5 at Buffalo +8.5, Total 42 - Matchup Report

Trends: The total has gone OVER in 5 of Cincinnati's last 5 games when playing Buffalo.
The total has gone OVER in 5 of Buffalo's last 5 games when playing Cincinnati.

Pittsburgh PK at NY Jets PK, Total 40.5 - Matchup Report

Trends: The total has gone UNDER in 5 of Pittsburgh's last 5 games when playing on the road against NY Jets.

Steelers are 3-10 ATS past 13 road games.

Jacksonville +26.5 at Denver -26.5, Total 53 - Matchup Report

Trends: Jacksonville is 5-1 SU in its last 6 games when playing Denver.
Denver is 5-0 SU in its last 5 games.

Tennessee +14.5 at Seattle -14.5, Total 40 - Matchup Report

Trends: The total has gone UNDER in 5 of Tennessee's last 5 games when playing on the road against Seattle.
Seattle is 5-0 SU in its last 5 games at home.

New Orleans +2.5 at New England -2.5, Total 49.5 - Matchup Report

Trends: New Orleans is 5-0 SU in its last 5 games. 
The total has gone UNDER in 5 of New England's last 6 games.

Arizona +12.5 at San Francisco -12.5, Total 41.5 - Matchup Report

Trends: The total has gone UNDER in 4 of Arizona's last 5 games. 
San Francisco is 7-1 SU in its last 8 games when playing Arizona.

Washington +7 at Dallas -7, Total 53 - Matchup Report

Trends: The total has gone OVER in 4 of Washington's last 5 games on the road.
The total has gone OVER in 6 of Dallas's last 7 games at home.

Indianapolis PK at San Diego PK, Total 49 - Matchup Report

Trends: The total has gone UNDER in 5 of Indianapolis's last 5 games on the road.
San Diego is 5-1 SU in its last 6 games when playing Indianapolis.