College Football Week 6 Picks: Texas Longhorns vs. Iowa State Cyclones

The Texas Longhorns are 4-2 against the spread as road favorites the last two-plus seasons, which is important to consider when making your college football Week 6 picks Thursday, as they prepare to take on the Iowa State Cyclones at Jack Trice Stadium.

Sports bettors will find that the Longhorns are 8.5-point favorites in the NCAA football odds, while the betting total hasn't been established in the market.

Let's take a closer look at this Big 12 Conference matchup from a betting perspective, while offering up a prediction along the way.

Gambling stats via SBR Forum

Texas Longhorns

Ronald Martinez/Getty Images

The Texas Longhorns snapped a two-game losing streak by picking up a 31-21 victory over the Kansas State Wildcats as six-point home favorites Sept. 21, but quarterback David Ash didn't play the second half due to a head injury.

College football handicappers will find that the road team has covered the number in six of the last seven meetings in this series.

Iowa State Cyclones

Spruce Derden-USA TODAY Sports

The Iowa State Cyclones are 22-1 under head coach Paul Rhoads when allowing fewer than 24 points in a game, as they come off a 38-21 victory over the Tulsa Golden Hurricane as three-point road underdogs Sept. 26.

Over the last two-plus seasons, the Cyclones are 5-2-1 against the spread as underdogs of 3.5 to 10 points.

Prediction

I'm going to recommend that readers back the Texas Longhorns, as they've won all four of their road meetings against the Iowa State Cyclones by an average of 25 points.

College Football Pick: Texas Longhorns -8.5

Follow on Twitter: @JeffGrantSports