Denver Broncos vs. New York Giants: Betting Odds Preview, Prediction

The New York Giants have been home underdogs just five times since 2006, but they face that role Sunday in the latest edition of the Manning Bowl.

Denver, led by Peyton Manning, is laying minus-five on the road to brother Eli's Giants, who have risen to the challenge as a home dog, going 4-1 ATS in those games, according to the NFL database at OddsShark.com.

The total was hovering around 56 early in the week but had been bet down to 55 at some online shops and in Vegas.

Both of Archie's sons had monster games in Week 1; however, the younger Manning was picked off thrice in a 36-31 loss to the Dallas Cowboys, where the Giants lost for the first time in four trips as a three-point underdog.

The season kicked off in Denver last Thursday, when Peyton was 27-of-42 for 462 yards with seven touchdown passes and no interceptions in a 49-27 win over the defending Super Bowl champion Baltimore Ravens.

Three days later, on the Sunday night NBC game, Eli was 27-of-42 for 450 yards with four touchdown passes and three interceptions.

And while Peyton overcame a slow start and a 33-minute lightning delay to throw for 462 yards—the fourth-highest total in an opener—and found a couple of new targets in tight end Julius Thomas and offseason acquisition Wes Welker, it was Eli who utilized a trio of wideouts who all had impressive performances despite the loss to Dallas.

Victor Cruz, Hakeem Nicks and Rueben Randle all tallied more than 100 yards receiving. Cruz had five catches for 118 yards and three touchdowns, Nicks had five catches for 114 yards, and Randle had five catches for 101 yards.

Looking to rebound from the loss and playing at home, Eli's receiving trifecta could cause problems for Denver's defense, which saw cornerbacks Champ Bailey (foot) and Omar Bolden (shoulder) and middle linebacker Wesley Woodyard (ankle) miss Monday's practice.

The Broncos arrive in Jersey on betting win streaks of 5-1 while ordering room service, 7-2 against losing teams and 4-1 after winning on the field.

Conversely, the Giants have lost four consecutive games straight up dating back to last season but have covered 11 of 15 against winning teams and are 9-4 ATS in the second week of the season.

Prediction: 38-31 Denver (courtesy of OddsShark.com computer)