MLB Picks: Oakland Athletics vs. Pittsburgh Pirates

The Pittsburgh Pirates are 16-7 in their last 23 interleague home games, which is important to consider when making your MLB picks on Wednesday as they take on the Oakland Athletics at PNC Park.

Courtesy of SBR Forum, the Pirates are minus-129 favorites in the pro baseball odds, with the total sitting at 7.5 in the market.

Let's take a closer look at this matchup from a betting perspective, while offering up a prediction along the way. 

Oakland Athletics

The Oakland Athletics have won 10 of their last 13 games, including a 2-1 victory over the Pittsburgh Pirates on Tuesday night.

Athletics starting pitcher Tommy Milone is 5-0 with a 5.00 ERA in 12 career starts versus National League opponents. 

Pittsburgh Pirates

The Pittsburgh Pirates are mired in a season-high-tying four-game losing streak, with the offense scoring six runs over that span.

Pirates starting pitcher Francisco Liriano is 2-0 with a 2.04 ERA in two career starts with umpire Alfonso Marquez behind home plate.  

Prediction

I'm going to recommend that readers back the Pittsburgh Pirates as one of their MLB picks on Wednesday, as they've won seven of their last eight interleague games as favorites of minus-110 to minus-150.

MLB Pick: Pittsburgh Pirates minus-129

Follow on Twitter: @JeffGrantSports