NCAA Basketball Picks: Iowa State Cyclones vs. Kansas Jayhawks

The Kansas Jayhawks (12-1) own the nation's second longest active home winning streak. They prepare to take on the Iowa State Cyclones (10-3) at Allen Fieldhouse on Wednesday night, with the opening tip scheduled for 7 p.m. ET on ESPNU.

Sports bettors will find that the Jayhawks are 13-point home favorites in the college basketball betting odds (courtesy of SBR Forum), while the total sits at 149 in the market.

With a 69-62 win over the Temple Owls last weekend, Kansas secured its 30th consecutive victory in front of its home fans.

Let's take a closer look at this Big 12 Conference affair from a betting perspective, while offering an against-the-spread (ATS) look along the way. 

Iowa State Cyclones

The Iowa State Cyclones have lost and failed to cover the spread in all three of their games as underdogs this year, but they've won their last four games heading into Wednesday night's matchup against the Kansas Jayhawks.

Sports bettors will find that the underdog is 4-1 ATS in the last five meetings in this series, while the Cyclones are 12-2 ATS on the road when getting 12.5 to 15 points. 

Kansas Jayhawks

The Kansas Jayhawks have won 21 straight conference openers, but they've gone just 14-14 ATS as home favorites of 12.5 or more points since 2010.

Sports bettors will also find that the program has failed to cover the spread in its last three home games when the total is between 145 and 149.5. 

Prediction

I'm going to recommend that readers back the Iowa State Cyclones as one of their college basketball picks, as they're the only team in the country to score 70 or more points in every game this season, while outrebounding 12 of 13 opponents.

Kansas wins in straight-up fashion, but will fail to cover this double-digit number.

College Basketball Pick: Iowa State Cyclones +13

Follow Jeff Grant on Twitter