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First off, thank you for becoming a fan. I appreciate that, Leeski.
I don't believe Holmgren would be a good fit in Arizona. He would require too much power (i.e. Cleveland). Graves and Mike Bidwill are doing a fine job. The problem isn't with them—though, the offensive line woes are on them, injuries or not because of the lack of quality depth.
The problem is with the injuries the team has sustained this season. Now three starting offensive linemen have missed time; the top two running backs; both quarterbacks have missed time; Todd Heap.
The offense has been ravaged all season. It is my belief they would be in a much better position if they were a healthy team. The line would not be great, but they certainly would not be sitting at 41 sacks allowed through eight games. Better protection—with either Kolb or Skelton—would lead to a more consistent offense.
San Francisco built their line largely from the draft. Three of their starters—left tackle Joe Staley (2007), left guard Mike Iupati (2010) and right tackle Anthony Davis (2010)—were drafted in the first round.
Everyone is playing well because they have talent on the ends and talent inside. They got rid of the weakest link from the past few seasons (also known as the Cardinals' starting right guard, Adam Snyder).
They drafted themselves into an all-star offensive line. Arizona has not done that, and that's why they continue to struggle.