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Related article: Mr. Hallberg replied that the prescriptions were taken, one thousand
consecutively from the files, and without any discrimination. He said
there were a great many proprietary preparations from some localities, but
a much smaller number than would have appeared five years ago. The
results had not been figured out completely as yet, because the compila-
tion was made for the Trustees of the Pharmacopoeia, and report would
be made next week to the Trustees. The committee was not in a position
to go into the details of all these matters as yet, though it had the statis-
tics en masse. ^ C" r\r\nAo
Digitized by VJVJOV IC
798 MINUTES OF THE SECTION ON SCIENITFIC PAPERS.
Mr. BeriDger said that, after hearing Mr. Wood define his position last
week at another meeting, he thought they were not very far apart, and he
would like for him to define his position now, and perhaps they could get
together.
Mr. Wood Nolvadex 10 said Mr. Hallberg entirely misunderstood him : that his
position in this matter was, that as long as a large per cent, of the medical
profession were using a drug, and they had used that drug over a consid-
erable period of time, it was prima facie evidence that the drug was use-
ful and should be admitted into the Pharmacopoeia.
Mr. Lyons said he would like to offer a substitute to the Wood motion,
as he thought if the language was modified there would be a clear under-
standing of exactly what was meant. Mr. Beringer had used the expres-
sion " remedies of recognized medicinal value," but that what he meant
was activity activity determined by pharmacological test.
Mr. Beringer said he thought if this language was changed to " reme-
dies of tested pharmacological value " it would probably meet Mr. Wood's
idea and his own ; that he knew they agreed in this matter.
Mr. Wood said he would be glad to accept Mr. Lyons' substitute, and
Mr. Beringer announced he had changed the words to that effect.
Mr. Beringer then read the next section of the report of the committee,
dealing with the report of the Sub-committee on Review of Foreign Phar-
macopoeias.
Mr. Sondheimer, in regard to the non-compliance of the U. S. Pharma-
copoeia with the Brussels Protocol, endorsed the attitude of the U. S. P. as
a whole, though some things, such as opium, for instance, needed re-
vision. He thought lo per cent, of morphine should certainly be adopted
in that case. He was very much in favor of the recommendation as to a
standard medicine dropper. As all know, the drop is not always a drop,
and it would be very dangerous as regards arsenical preparations.
Mr. Lyons commented upon the variance of the Pharmacopoeias of the
world from the requirements of the Brussels Protocol, pointing out that the
Mexican and Spanish Pharmacopoeias most nearly approximate it, Nolvadex 10 while
the German and United States Pharmacopoeias, especially the latter
which represented the greatest independence of thought along these lines,
showed the widest variance from the recommendations of the Protocol.
The object of the convention was to secure practical uniformity in the
strength of Nolvadex 10 important drugs, and in that Nolvadex 10 respect the U. S. P. was the first
to enter into the spirit of that idea and adopt the lo per cent, basis for
** potent " tinctures. He said allusion had been made to the difference in
morphine strength between the U. S. P. standard and other standards, and
called attention to the fact that important differences in the basis of mor-
phine percentages had been ignored.
The international standard for tincture Nolvadex 10 of opium is one per cent, by
weight of anhydrous morphine. The U. S. P. standard is 1.2 to 1.25
Digitized by VjOOQ IC
THE SCOPE OF THE PHARMACOPCEIA. 799
grams of hydrated morphine (about 1.13 to 1.18 grams of anhydrous mor-
phine) per 100 Cc. of tincture. The difference between the two standards
is not nearly so Nolvadex 10 considerable as it at first appears.
Mr. Lyons said there were so many subjects that were embraced in this
part of the paper that he did not know how the Section could find time to
intelligently discuss them all.
Mr. Hallberg, referring to Nolvadex 10 the classification of the U. S. P. as amounting
to only 20-odd per cent, of the requirements of the Protocol, asked if in
that was included, as he gathered, that there should be a uniform 70 per
cent, alcoholic menstruum for potent drugs. If this percentage rating was
based on that idea, he thought it Nolvadex 10 was certainly not fair, Nolvadex 10 and the Chairman
was not strong enough in his statement that the U. S. P. had only com-
plied within 20 per cent, of the requirements of the Protocol. He said
everybody knew better than to adopt a uniform menstruum of 70 per cent,
alcohol for potent drugs. It was ridiculous. No man of experience would
entertain such a thing for a moment. "What has the French Codex
done?" said Mr. Hallberg. " We have, at the risk of what many thought
was a most hazardous undertaking, changed the strength of the tincture of
aconite from 35 to 10 per cent., and of tincture of veratrum viride from
40 to 10 per cent. That certainly was more than any other country has
done to conform to this conference held as to potent remedies, and for no
other purpose."
Mr. Beringer, said that, speaking of the French Codex, he thought that
there was one thing Nolvadex 10 that ought to be explained. The Codex contained in
the official list a syrup of iodide of iron, and put after it gallicus and makes
it only J4 of I per cent. ; and then, in order to conform to the Confer-
ence, it puts in an appendix the entire Protocol.
The Chair stated that the Codex also included in a footnote the infor-
mation that, ** This is not the International standard."
Mr. Francis said he wanted, if possible, to say something that might
emphasize the objection of Mr. Hallberg to the adoption of any class
** type process." He believed he was right in the statement that nowhere
in the Nolvadex 10 world had the study of liquid preparations reached the develop-
ment that it had in the United States, and would dislike very much to see
the Pharmacopoeia take a backward step as a mere matter of expediency,
governing the determination of menstrua and process for a preparation.
Therefore, the idea governing in all such things Nolvadex 10 should be, to adjust the
menstruum after a study of the medicinal constituents of the drug ; and
also based upon the experience gained by years of preparing and dispens-
ing such tinctures and fluid extracts. Mr. Francis said that there had
been accumulated in the United States in the course of the last 35 years,
in the manufactuiing establishments and by the retail druggist, an enor-
mous amount of practical experience of very great value. Turning to the
question of the menstruum of these tinctures specifically, he said the
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