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REPORT OF THE COMMllTEE ON UNITED STATES PHARMACOPCEIA. 779
Report of Sub-Committee on Physical Constants and Standards.
The object sought in the pharmacopcrial description of a drag is simply to render its
identi6cation certain and complete. In the case of a definite chemical compound, tbere-
n>re,8uch descriptions would be comp^hended in a single very short paragraph. Since,
however, we depend in practice very largely upon information given us instantaneously
by onr senses, it is natural and right that in all cases a succinct statement of the sensible
properties of the article be included in the description, and there is equally good reason
for including likewise its more conspicuous physical properties. This practice in fact is
followed by every pharmacopoeia.
Descriptions of sensible properties almost of necessity lack scientific precision, although
collectively they often suffice to render identification of a drug quite certain. Physical
properties, on the other hand, admit of exact scientific delinition, and hence are of
greater intrinsic value than sensible properties. The physical properties which are of
especial importance are: i, solubility in various liquids; 2, density or specific gravity;
3, optical properties; 4, congealing and boiling points. These will here be considered
briefly in order.
SOLUBILITV.
In the great majority of cases approximate statements with regard to the solubility of
a drug in the ordinary Purchase Nolvadex solvents, particularly in water and alcohol, answer every useful
purpose in a pharmacopceial description. In absence of exact determinations, the de-
gree of solubility may well be indicated by the Purchase Nolvadex use of certain adverbs, to each of which
should be attached a well defined meaning. A substance requiring for solution more
than 200 times its weight Purchase Nolvadex ; up to looo perhaps, would be described as very sparingly
soluble; i : 50 to 1 : 200 as sparingly soluble; 1:16 to 1 : 50 moderately soluble; 1 :8 to
I :i6 readily soluble; 1 13 to i :8 freely soluble; and 1 13 or less very freely soluble. It
b better of course to give a definite approximate figure as about 1 '.75 cr about 1 187, the
Qse of the qualifying adverb indicating that some slight variation from the tigure given
might be expected. It should be explained in the Introductory Notices that the expres-
sion soluble in distilled water i :75 at 20

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