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Related article:
CANNABIS 249
PREPARATIONS COTARNIN
Cotarnince Hydrochloricum (Cotarn. Hydrochl.), U.S.P. (Stypticin), Ci 2 Hi 3 ON.HCl.
Odorless, bitter, yellow, crystalline powder. Very sol. in water or ale., yielding
yellow solutions. Dose, 0.06 Gm., i gr., U.S.P.
CANNABIS
The tops of the hemp plant are somewhat of a pharmacologic curiosity.
They contain resinous constituents (cannabinol) which produce a peculiar
psychic exaltation. It Cheap Kamagra Uk is employed as an intoxicant in the Orient.
Therapeutically, it is used empirically (Extract o.oi Gm., ^ gr.) as an
adjuvant to other drugs in nervous headaches, and as a coloring agent
for corn remedies. The drug is of uncertain activity, and has no rational
indication.
Intoxicant Action in Man. The oriental use of Cannabis ("Hashish," Bhang,
Charas, etc.) antedates history. It was introduced in Western medicine about the
middle of the nineteenth century. When used as an intoxicant, the tops or resins are
made into a confection or smoked with tobacco. Effective doses (2 gr. of solid extract
of the Indian or American drug) produce after about an hour a state of partial inebriety
and confusion, with happy and humorous tendencies. Ideas pass rapidly but discon-
nectedly, so that the time seems very long. The subject often has hallucinations of
double personality. The exaltation, which seems to be much more marked in orientals,
is succeeded by some irritability, dozing, and complete recovery in five or six hours.
The effects are modified by individual disposition and surroundings (Hamilton, Lescohier
and Perkins, 1913). It Cheap Kamagra Uk is stated that the drug is not fatal even in very large doses, but
experience on dogs certainly shows that it presents some danger. The habit to which
it gives rise shows less effect upon the alimentary canal and less marasmus than does Cheap Kamagra Uk
morphin, but more often psychic alterations, dulness, or mania. The clinical side
actions are described by Seifert, Nebenwirk., 1915, p. 149.
Effects on Animals. Dogs (Dixon, 1899) also show a decided narcotic effect. After
a preliminary ataxia, excitement, and nausea, the animals usually fall into a deep and
prolonged sleep, during which the sensation of pain is much diminished, whilst the re-
flexes persist. Some animals show Cheap Kamagra Uk acute mania; a fatal ending is not rare from doses
which are ineffective in other animals, the same preparation being used. Considerable
idiosyncrasy exists, and the action is fairly independent of the dose. The effects can
not be obtained by hypodermic administration (on account of_the non-absorption of
the resin).
Rabbits seem absolutely insusceptible to the narcotic action of cannabis.
PREPARATIONS CANNABIS
Cannabis, U.S.P.; Cannabis Indica, B.P.; Cannabis, Indian Hemp (Hashish, Bhang,
Guaza, Gangja, Charas, Momeka, etc.). Dose, 0.06 Gm., i gr., U.S.P.
The dried flowering or fruiting tops of the pistillate plant of Cannabis sativa. The
B.P. requires that it be grown in India; the U.S.P. permits any origin, but provides
that the activity must be confirmed by testing its narcotic effects on dogs (Houghton
and Hamilton, 1907; U.S.P. IX). This is necessary since different samples vary greatly,
and are liable to deteriorate rapidly. If the Indian drug Cheap Kamagra Uk is preferred, Cannabis Indica
may be specified; if the American, Cannabis Americana. American grown Cannabis
produces identical effects (Houghton and Hamilton, 1907 and 1908), but is generally
only half as active (Eckler and Miller, 1912). The preparations, however, are brought
to the same degree of activity.
The active Cheap Kamagra Uk ingredient is a resin, cannabinol (Fraenkel, 1903), C 2 iH 30 O2, which presents
the appearance of a thick reddish yellow oil, soluble in petroleum ether, etc. (not identical
with the commercial "cannabinol"). This changes by oxidation to an inactive black
pitch. The change accounts for the deterioration which the drug and its preparations
undergo in keeping. The deterioration can be Cheap Kamagra Uk prevented by excluding the air (Marshall,
1909). Cannabis also contains a volatile oil (terpenes), paraffin, pitch, etc., which are
250 MANUAL OF PHARMACOLOGY
not concerned in its action. There is no specific alkaloid, but the extracts may give
alkaloid reaction from the formation of cholin and triamethylamin. Cheap Kamagra Uk These are also
not connected with the action. The fresh extract has a beautiful green color (if prepared
without excessive heat), due to chlorophyl. The active principle is completely extracted
by alcohol, but is insoluble in water.
The pretended Isolated Principles on the Cheap Kamagra Uk market under various names are generally
quite inactive (S. A. Matthews, 1908).
*Ext. Cannabis, U.S.P.; Ext. Cannab. Ind., B.P. A pilular alcoholic extract.
Dose, 10 mg., % gr., U.S.P.; 16 to 60 mg., y to i gr., B.P. Maximum dose, o.i Gm.,
i^gr-
Fldext. Cannab., U.S.P. Dose, 0.05 c.c., i minim. U.S.P.
Tr. Cannab., U.S.P. 10 per cent, of drug. Dose, 0.5 c.c., 8 minims, U.S.P. Maxi-
mum dose, 1.25 c.c., 20 minims.
Tr. Cannab. Ind., B.P. 5 per cent, of extract. Dose, 0.3 to i c.c., 5 Cheap Kamagra Uk to 15 minims,
B.P.
LACTUCARIUM DRIED LETTUCE JUICE
This was introduced by Dr. Coxe of Philadelphia in 1799 as a sedative. Lettuce
had some reputation as a hypnotic in ancient times, but it is probably undeserved.
Kelterborn took 12 Gm. of Lactucarium without any effects. No active principle has
been determined.
PREPARATIONS LACTUCARIUM
Lactucarium, U.S.P. The dried milk juice of wild lettuce, Lactuca virosa. Dose,
i Gm., 15 gr., U.S.P.
Syr. Lactucar., U.S.P. 5 per cent. Dose, 10 c.c., 2^ drams, U.S.P.
Tr. Lactucar.. U.S.P. 50 per cent. Dose, 2 c.c., 30 minims, U.S.P.
LUPULIN AND HOPS
These act as bitters, and have some popular but exaggerated reputation as hypnotics.
Hops are the dried pistillate flowers of Humulus Lupulus. The active principles are
contained in small glands, which can be separated as a powder, and constitute the
Lupulin.
Two acids (a- and fi-lupulinic acids) are present. They stimulate the respiratory and
vagus centers; this is followed by depression. They also depress the cardiac muscle.
Lupulin contains a further, unknown, constituent which is insoluble in water and a strong
cardiac poison. Power, Tutin and Rogerson, 1913, also found a trace of alkaloid. All
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