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Related article: Pumpkin or Melon Seeds, fresh or at least not over a year old, are eaten in % ounce
doses, on the day preceding the regular treatment. They are not sufficiently active
themselves, but serve to support other measures. They were investigated chem-
ically and pharmacologically by Power and Salway, 1910; but none of the constit-
uents had any action on the host or parasites. Weinblum, 1912, found neither alka-
loids nor glucosids, and also considers the action very unreliable. The fresh "milk" of
the cocoan-ut is also said to be anthelmintic.
Spigelia, U.S.P.; (Pink Root). The dried rhizome and roots of Spigelia marilandica.
It is said to stupefy Buy Anafranil Online round worms. It contains a bitter acrid resin; a poisonous alkaloid;
volatile oil, etc. Little is known of its action. Toxic effects, which are rare, resemble
those of pelletierin. Dose, 4 Gm., 60 gr., U.S.P. Buy Anafranil Online
Fldext. Spigcl, U.S.P. Dose, 4 c.c., i dram, U.S.P.
Butea Semina, B.P.; Butea Seeds. The seeds of Butea frondosa. Used in India
as anthelmintic.
Pitlv. Butea Sent., B.P. Dose, 0.6 to 1.2 Gm., 10 to 20 gr., B.P.
SANTONIN
General Statement. Santonica has been a favorite remedy against
round worms since Dioscorides. It is also used against pinworms if these
have ascended beyond the reach of enemas. It does not seem to kill the
ascaris, either in the intestine or in vitro, but they attempt to escape from
it and thus flee into the large intestine, whence they are evacuated by Buy Anafranil Online a
purgative. Santonin is insoluble, non-irritant and almost tasteless, and
is therefore easily administered to children. It may be mixed with some
sugar, and combined with calomel or castor oil, which does not increase
its absorption. To children of two to five years, 0.03 Gm., ^ gr., may be
given every hour for two or three doses, according to age, and then not
repeated for at least three days. The adult dose would be three times as
much. It should not be given on an empty stomach, since Buy Anafranil Online this would
favor absorption.
Santonin is the lacton of santonic acid. It is dissolved in the intes-
tine as sodium santoninate, and the greater part is eliminated unchanged
in the feces. A small amount is absorbed, oxidized, and the derivatives
(especially the crystalline Santogenin, Jaffe, 1890) are excreted by the
urine. An unknown derivative imparts Buy Anafranil Online a bright yellow color to the urine
when acid, changing to pink when alkaline.
Doses but little above the ordinary cause " yellow vision," persisting
for some hours, without other bad effects. Overdoses produce serious
poisoning. Santonin should therefore only be sold on prescriptions. The
Troches, by their resemblance to candy, are especially liable to produce
accidental poisoning.
Action on Worms ; Relation to Structure. This has been studied by Trendelenburg,
1915, on rain-worms, leeches and ascaris. It consists in strong stimulation (increased
tonus and contractions) of the muscle, persisting after removal of the ganglia. The
effect is highly specific, since it is not produced in anything like the same degree by other
substances (although some alkaloids have a weak action); nor does santonin stimulate
vertebrate muscle. It is connected with the lactone structure, as is also a depressant
effect on the isolated frog heart. The convulsant effect on mammals, on the other hand,
does not depend on the lactone, but on the naphthalin nucleus.
184 MANUAL OF PHARMACOLOGY
The Phenomena of Severe Intoxication. These are vomiting, colic
and diarrhea, painful micturition, hematuria, headache and vertigo, weak-
ness, somnolence; finally convulsions (which may be unilateral), and fall
of temperature (Binz, 1877; Harnack, 1901).
The Treatment. This would consist in evacuation; chloroform in-
halation Buy Anafranil Online against the convulsions; and stimulants against collapse.
Fatal Dose. In children, 0.06 Gm., i gr., has produced serious poisoning, and two
such doses have been fatal; in other cases, 0.18 Gm., 3 gr., caused only light symptoms,
and recovery has occurred after 0.72 Gm., n gr. By adults, 0.5 to i Gm. and more
have been taken without damage (Lewin).
The Color of the Urine. This may be confused with that of emodin (rhubarb, etc.).
The emodin colors can be shaken out with ether, or precipitated by lime or barium
water, whilst the santonin color can not.
Uric Buy Anafranil Online Acid Elimination. This is increased by Santonin, as by other intestinal irri-
tants (Abl, 1913).
Xanthopsia. Doses as small as o.i Gm. may cause "yellow vision" i.e., white
light has at first a violet, then a yellowish-green hue, and these colors tint the entire
field of vision. The power of seeing in dim light is also lessened. It has been demon-
strated that these effects are peripheral (Knies, 1894), and the theory is advanced,
based on some experimental data, that santonin impairs the reproduction of the visual
purple and violet, which are at first used very rapidly. There is no truth in the state-
ment that it discolors the media of the eye (Filehne, 1900).
Colored vision also occurs, but more rarely with amyl nitrite, picric or chromic
acid, and digitalis (de Schweinitz, 1899).
PREPARATIONS SANTONIN
* Santoninum (Santonin.), U.S.P., B.P.; Santonin, CisHigOs. The inner anhydrid
or lacton of santonic acid obtained from Santonica. Colorless crystals (turning yellow
on exposure to light) ; odorless and nearly tasteless when first placed in mouth, but after-
ward developing a bitter taste. Very slightly sol. in water, sol. in ale. (1:43). Dose,
0.06 Gm., i gr., U.S.P.; 0.06 to 0.2 Gm., i to 3 gr., B.P.; in powder, with a Buy Anafranil Online little sugar. Buy Anafranil Online
Maximum dose, 0.2 Gm., 3 gr.
Santonin has been used in epilepsy and in diabetes, but with little success.
Santonica, "Levant Buy Anafranil Online Worm-seed" (really the unexpanded flowerheads of Artemisia
pauciflora), also contains cineol, but this has no action on ascaris (Bruening, 1912).
Troch. Santonin., B.P.; Santonin Lozenges. Each contains 0.06 Gm., i grain.
VERMICIDES FOR THREAD WORMS (OXYURIS)
These are usually treated most efficiently by the rectal injection of
various irritants. The rectum is first washed with injections of iron,
tannin, or bitters (quassia,) to limit the secretion of mucus, and is then
irrigated with solutions or emulsions of salt (5ss to pt.), Buy Anafranil Online aloes (3j to pt.),
or turpentine (3ij to pt.), etc. Mercury salts are sometimes used as in-
jection or suppository, but are dangerous.
CONVULSANT POISONS
Convulsions may be caused by direct stimulation of the muscles (ver-
atrin) ; or of efferent motor nerves (physostigmin, aconitin) ; ftr by reflexes
from strong afferent stimulation; or by stimulation of the motor centers
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