NFL Week 16 Picks: San Francisco 49ers and Teams Sure to Cover the Spread

Michael MillSenior Analyst IIIDecember 23, 2011

SAN FRANCISCO, CA - DECEMBER 19: Alex Smith #11 of the San Francisco 49ers drops back to pass against the Pittsburgh Steelers at Candlestick Park on December 19, 2011 in San Francisco, California. The 49ers won the game 20-3. (Photo by Thearon W. Henderson/Getty Images)
Thearon W. Henderson/Getty Images

With only two games remaining in the season, it's really difficult to find many holes in the spread determined by Vegas.

At this point in the season, it's pretty clear which teams are favorites and which are the underdogs.

Early in the season you can typically pick apart the flaws in the spread.

Now, there are very few teams you can feel safe betting on. There still are a few that look like good picks this weekend.

Here are three teams sure to cover the spread.

San Francisco 49ers

The fact that they are coming off a very short week may have something to do with the determined spread, but you can still feel safe going with the 49ers.

San Francisco is only one-point favorites over the Seattle Seahawks this weekend.

So, if they win the game they cover the spread.

The Seahawks have one of the more underrated defenses in the league, but I can't see them generating enough points to walk away with the win.

Seattle relies heavily on their run game, which should be very limited against this stout San Francisco defense.

San Diego Chargers

The San Diego Chargers are hot right now as they make a final effort and push to make it into postseason play this season.

The Lions have been faltering recently and find themselves in a similar situation.

The game is a must win for both teams.

The Lions are two-point favorites, but the matchup favors the Chargers.

San Diego has a top-tier pass defense to take on the Detroit pass-happy offense. Almost every matchup favors the Chargers.

Throw in the fact that they have the momentum, and you should feel safe betting on them.

Carolina Panthers

If I were to tell you that Carolina was 7.5-point favorites this weekend, most of the time that would be a reason to bet against them.

This weekend, that's not the case.

The Panthers are taking on one of the complete worst teams in football. The Tampa Bay Buccaneers have had no offense or defense at all this season.

Carolina crushed Tampa Bay in Week 13 by a final score of 38-19.

I wouldn't expect different results this time around.

In fact, it could be worse. Carolina continues to improve each week while the Buccaneers continue to fall apart.