He will go up against former Strikeforce heavyweight champion Alistair Overeem in one of the year's most anticipated bouts.
It was recently determined that the winner of the bout will face current UFC heavyweight champion Junior dos Santos, who defeated Cain Velasquez on the first UFC on FOX show.
After a second fight with diverticulitis, Lesnar will return to the cage for the first time in over a year. He was last seen getting pummeled by Velasquez in his third defense of the heavyweight championship in October 2010.
Overeem will enter the bout with an extensive 35-11 record, including a current 10-fight win streak with victories over Brett Rogers, Fabricio Werdum and Kazuyuki Fujita.
This video features predictions from Wanderlei Silva, Manvel Gamburyan, Kevin Randleman, Martin Kampmann and Master Rafael Cordeiro.