Oklahoma State's Best Hope: That Weeden-Blackmon really is the most dominant QB-WR tandem in college football today. Weeden (4,328 yards, 34 TD, 12 INT) has a better completion rate than RG3 (72.6 percent), and part of that is because he's throwing to two-time Biletnikoff winner Justin Blackmon (1,336 yards, 15 TD).
Weeden-Blackmon lead an offensive corps that has churned out an average of 49.3 points per game this season. Stanford had trouble with Oregon's lightning offense, where its main worry was rushing. Facing another speedy opponent that excels in the passing-receiving game and the rushing game (OK State's leading rusher Joseph Randle has 1,123 yards and 23 TDs) should be enough to give Cardinal fans pause.
Stanford's Best Hope: Heisman runner-up Andrew Luck, but not for the reasons most people talk about.
His numbers (3,170 yards, 35 TD, 9 INT) are fairly comparable to Weeden's despite lacking a strong receiving corps. That very lack of a deep-field threat has forced Stanford, which likes to play smash-mouth, pro-style football, to get creative with its run sets.
Luck passes to his three tight ends (most often senior Coby Fleener who has 10 TD this season) to move the ball in short, steady bursts across the field. He is exceptional at dissecting a team's defense versus the run, and it is because of him that the Cardinal is 26th and 22nd at passing and rushing respectively.
Prediction: Oklahoma State does not have a strong rush defense, so there is no reason to suspect they will stop Luck's penetrating throws. The Cowboys also don't have a strong pass defense, meaning WR Griff Whalen—while no Blackmon—will still see touches, especially after coming up big in games against Oregon and USC.
Actually, with a defense that is ranked 107th nationally, there is no reason to suspect that the Cowboys will stop Luck's Cardinals in any way.
Of course, even though Stanford boasts a Top-25 defense, there is no reason to suspect it can stop Oklahoma State's offense, which overpowered Texas's stronger defense. And the Cardinals were blown away by Oregon, which boasted a similar high-powered offense.
Oklahoma State has only faced Texas in terms of good defense, and they won that by two touchdowns. Stanford has a stronger secondary than Texas, one that faced down USC's Matt Barkley and his talented receiving corps, and it certainly has a better offense.
Oklahoma State 40, Stanford 48