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In recent seasons, Arsenal's away form has been their undoing in the UEFA Champions League and many may be concerned that the Milan tie could be over after the first leg.
But the Gunners have been far more defensively stout and resolute in this season's competition. Aside from defeat to Olympiacos in Athens in what was essentially a dead game, Arsenal have fared very well in some tough destinations so far.
Wenger's team claimed an impressive 1-1 draw in Dortmund in their initial group match and took all three points after a fine 1-0 win in Marseille, courtesy of Aaron Ramsey's injury time winner.
In fact, only a late wonder strike in Germany denied Arsenal six points from these two difficult away trips. The Gunners have been more compact, ruthless and efficient on their European travels this season.
This should give the team an abundance of confidence for the trip to Italy and provides real hope that Arsenal can secure a positive result in the San Siro.