The Rangers fell to the Blues 4-1, and were unable to generate many offensive chances against a Blues team that leads the league in goals against per game, and shots against per game.
Brian Elliot made 25 saves, although he was able to see almost every shot, and didn't have to face second-chance opportunities.
The Blues got on the board seven minutes into the first period. After Henrik Lundqvist stopped Alex Steen's initial shot, Patrick Berglund outworked Brad Richards and Ryan McDonagh along the boards, and fired a wrist shot past Lundqvist's glove.
Four minutes later, the Blues struck again. David Perron was able to position himself in between the Rangers players and redirect Carlo Coliacovo's one-timer past Lundqvist to make it 2-0.
After the Blues' second goal, Rangers coach John Tortorella began to change the lines, hoping that some combination would be able to solve Elliot.
Brad Richards, who was on the ice for both St. Louis goals in the first period, didn't see the ice for the remainder of the first period after the Blues went ahead 2-0.
Lundqvist kept the Rangers in the game in the second period, making 13 of his 32 saves on the night.
Although the Rangers were outshot 13-5, they came away with the only goal of the period, as Michael Del Zotto took a pass from Brandon Dubinsky and beat Elliot with a backhander on the short side. The goal was Del Zotto's third of the season, one more than he had in 47 games last season.
Trailing by a goal entering the third period, the Rangers unfortunate "puck-luck" struck again.
Just over a minute into the period, Dan Girardi's clearing attempt hit Alex Steen, and the puck bounced off of Lundqvist's back and into the net. The Rangers couldn't generate many chances after that, and Jason Arnott capped off the scoring with an empty net goal for the Blues.
The loss snapped the Rangers' five-game winning streak on the road, and sends Tortorella and the coaching staff back to the drawing board hoping to find the right combinations for a team with one goal scored in their last seven periods.
The Rangers will try to snap their two game slide when they take on the Phoenix Coyotes on Saturday at 8:00 p.m. ET.