The winner between these two behemoths will move on to challenge current champ Junior dos Santos for the heavyweight title.
In the co-main event, a pivotal lightweight affair takes place when the surging Donald Cerrone meets with former top contender and Season 5 winner of The Ultimate Fighter Nate Diaz.
A lot of action will be taking place at the Mandalay Bay Events Center come two weeks from now, and here's what you can expect.
Efrain Escudero, the Season 8 winner of The Ultimate Fighter, returns to the Octagon against Jacob Volkmann.
Both Escudero and Volkmann are touted collegiate wrestlers, though they will likely nullify one another's ground prowess and be forced to stand and trade in the cage.
From there, "Hecho en Mexico" will assert the same heavy-handed strikes that downed Cole Miller and Evan Dunham.
Though Volkmann is tough enough to survive some hairy moments, he will be leaving the cage with his first defeat in the lightweight division.
Though he's gone 4-0 as a lightweight, Volkmann's performances in the Octagon aren't the most aesthetically pleasing to have graced the UFC.
Fighters who have turned in dull performances—like Eliot Marshall, Antonio McKee and Jon Madsen—have all suffered the UFC axe despite their impressive winning streaks.
Expect the same from Volkmann, who will suffer defeat at the hands of Escudero and will later be working his way back into the big show.
In the past, Sean Pierson has suffered defeat only to top-tier competition. Unfortunately, that's where he finds himself now, as the Canadian meets Dong Hyun Kim.
The former top contender is reeling from a knockout loss to Carlos Condit, which will have him taking no chances against Pierson, whose only way to win is by an errant punch.
Kim will assert his superior grappling skills, bringing the heavy hitter to the mat time and time again, where he'll grind out a workmanlike decision victory and send Pierson packing with a 1-2 record in the Octagon.
Though the Swede Alexander Gustafsson has looked ultra impressive as of late, his Achilles heel has always been his wrestling acumen.
Training alongside collegiate wrestling stud Phil Davis has rubbed off a bit, but it won't be enough to counteract the already adept skills of Vladimir Matyushenko, who has flirted with top-10 status for nearly his entire career.
Expect "The Janitor" to wade through the striking arsenal of "The Mauler," driving him to the cage and bullying him to the mat for the full 15 minutes en route to earning a decision win and reasserting himself in the light heavyweight class.
After succumbing to a contentious decision defeat at the hands of former contender Tyson Griffin, Manny Gamburyan now finds himself paired up against Diego Nunes.
The former title challenger is currently riding a two-fight skid, but he will pick up his first victory in more than a year when he squares off against the Brazilian.
Nunes is a wily striker, but considering he was taken down and controlled by the likes of Kenny Florian on the ground, Gamburyan should fare much better.
"The Anvil" takes a dominant decision victory, returning to the top of the division and working his way back towards the title.
Riddle is a prodigy. The Season 7 veteran of The Ultimate Fighter has procured all of his mixed martial arts bouts under the UFC banner.
At 5-3 in the organization, Riddle has shown that his size, strength and wrestling acumen can be the difference-maker on any given night.
Luis Ramos will help expedite those claims.
The Brazilian will suffer a decision defeat thanks to the staunch wrestling skills of the powerhouse Riddle, who will send Ramos packing with an 0-2 run in the Octagon.
Though Castillo hails from a wrestling background, he has shown he has some of the heaviest hands in his division.
His tendencies fall right into Anthony Njokuani's game, as the Nigerian is regarded as one of the more technical kickboxers among lightweights.
Castillo will hold a decided advantage on the ground, though his bravado will allow the duo to trade punches on foot, where a sure-fire knockout will be secured.
This featherweight affair is rounding out the main card of UFC 141 for a reason.
Time and time again, Phan has proven to be one of the more exciting men in the division thanks to his well-rounded skills and adept boxing arsenal.
Jim Hettes, though unproven, has shown to have a wide array of skills, though he's a particularly dangerous submission specialist.
This back-and-forth battle will feature Phan gunning for the knockout and Hettes trying to bring the fight to the mat. Expect this matchup to be an early candidate for "Fight of the Night."
In a lightweight encounter, fan favorites Nate Diaz and Donald Cerrone will meet in the co-main event.
Though a former title challenger in Jon Fitch graces the event opposite a rising star, there's a reason why the UFC is granting Cerrone and Diaz co-headlining honors.
Both men have consistently put on some of the best fights to grace the cage.
In their last outings, both Diaz and Cerrone took home "Submission of the Night" awards thanks to their aesthetically pleasing performances against Takanori Gomi and Dennis Siver, respectively.
When it's all said and done, these two will be the clear "Fight of the Night" recipients.
After an extended layoff due to injury, Jon Fitch returns.
In his last outing, the perennial contender was pitted against former two-time world champion BJ Penn, where the two battled to a controversial draw.
Now, Fitch has the opportunity to return to the win column opposite the heavy-handed Johny Hendricks.
Though Hendricks is perhaps the better wrestler of the two on paper, Fitch has the better MMA-versed grappling skills. This will aid Fitch in taking home a decision victory over the budding contender, moving the AKA product back into title contention.
In a battle between two heavyweight behemoths, Alistair Overeem and Brock Lesnar meet in the main event.
Though no title will be on the line between these former champions, the bout will be contested over the course of five rounds, and their records would indicate this fight won't reach the scorecards.
Whether it's the ground-and-pound assault of Lesnar or the striking acumen of Overeem, this fight will end before the final bell.
It's a bit of a stretch, but it's certainly not out of the realm of possibility.
Lesnar does not have nearly as much experience standing opposite a K-1 World Grand Prix champion, which will make him hesitant on the feet.
However, shooting for a double leg right off the bat wouldn't be the proper course of action either.
Expect to see Lesnar telegraph an initial attempt to bring the fight to the mat and Overeem to greet him with one of his infamous knees to the head. This will mark the beginning of the end where the Dutchman drums up an emphatic finish, cinching him "Knockout of the Night" in the process.