In the 43 meetings between the two teams, the Broncos have won 27 games; 18 of those (out of 26) they have won at home in the Mile High City.
The Patriots have lost both meetings in the playoffs when they've faced the Broncos.
The Broncos hope to continue their six-game winning streak this weekend and end the Patriots' five-game streak of their own.
History is on the Broncos' side. Let's look at the five most memorable Broncos vs. Patriots matchups of all time.
For a mere $5 you could get a seat at the first AFL game of all time between the Denver Broncos and the Boston Patriots at Boston University's Nickerson Field on September 9, 1960. The game had an attendance of 21,597 fans.
The Broncos wore a hideous yellow-and-brown uniform with vertically striped socks.
After getting down early in the second quarter after a 35-yard field goal made by the Patriots' Gino Cappelletti, Denver got on the board after Frank Tripucka threw a swing pass to HB Al Carmichael who took it 59 yards for a touchdown, putting the Broncos up 7-3 at halftime.
In the third quarter, HB Gene Mingo made a huge play when he returned a punt 76 yards for a touchdown. However, Mingo was also the placekicker and exhausted from the run back, he missed the extra point.
In an effort to get back in the game, the Patriots DB Chuck Shonta intercepted a pass and returned it 52 yards to set up a 10-yard touchdown pass from Butch Songin to Jim Colclough.
The Broncos hung on to win by a final score of 13-10.
The Broncos were down early in this one after touchdowns by Wes Welker and Benjamin Watson from Tom Brady. At halftime, the Broncos trailed 17-7 after Brandon Marshall caught an 11-yard touchdown pass from Kyle Orton.
The Broncos responded in the second half scoring 10 unanswered points with a kick by Matt Prater and another touchdown reception by Marshall.
The almost-automatic Matt Prater put the game away in overtime, clinching a victory for Denver 20-17.
The game was promising as the Broncos' new head coach, Josh McDaniels, led the Broncos to their fifth straight victory of the season. It actuality, it marked the beginning of the end for McDaniels, who led the Broncos to another win over the San Diego Chargers but went on to finish the season with an 8-8 record. The next season was even worse leading to McDaniels' eventual firing.
Much like this week, both the Broncos and the Patriots came into the game with winning records and the outcome having playoff implications.
In 1979, both the Broncos and the Patriots were 7-3. In this game, the Orange Crush would dominate from start to finish. The Broncos got on the scoreboard early after forcing a fumble and Rubin Carter picked it up and returned it for a two-yard touchdown. Ever since then, the Broncos never looked back.
In the first quarter alone, the Broncos put up 24 points, scoring on a 49-yard field goal by Jim Turner, a two-yard rushing touchdown by Rob Lytle and a seven-yard touchdown reception by Haven Moss from Craig Morton.
The Broncos continued to pour it on and the final score was 45-10. The Broncos ended up advancing to the playoffs while the Patriots were left out.
The Denver Broncos were facing the defending Super Bowl champs, the New England Patriots, in the AFC Divisional playoffs in the Mile High City.
It was a low-scoring game as the Broncos took a 10-3 lead into halftime after a touchdown run by Mike Anderson and a 50-yard field goal by Jason Elam.
The Patriots pulled the game within four points after a second Adam Vinatieri field goal.
But it was the huge interception by Champ Bailey that sealed the game for the Broncos. Champ picked off Tom Brady and returned the interception 100 yards only to be tripped up by Benjamin Watson right at the goal line and he was marked out at the one-yard line.
Mike Anderson took the ball into the end zone for the one-yard score, putting the Patriots behind by 11, a lead that proved insurmountable.
John Elway loved to play the Patriots.
Throughout his career, Elway was an undefeated 11-0 against the Patriots and it was this foe he faced to earn his first career playoff victory. This first playoff victory would be his first in the first run he had at the Super Bowl in 1986 season, only a week before his famous "Drive" against the Cleveland Browns.
Elway gave the Broncos an early lead after he scrambled for 22 yards into the end zone to give the Broncos a 10-7 lead. The Patriots followed up by tying the game at halftime with a 38-yard field goal.
In the third quarter, the Patriots took the lead after a 45-yard touchdown pass to Stanley Morgan from Tony Eason. However, it was Elway who had the final word with a 48-yard touchdown pass to Vance Johnson that sealed the game. The Broncos went on to win 22-17.
This week marks a new chapter in the Broncos history with the New England Patriots. This Broncos team is led by the rising star, Tim Tebow, who has improbably led the Broncos to six straight victories all in thrilling fashion.