Just as every dog has his day, every superstar will find himself grossly outmatched at some point in the season.
Unless you've got Aaron Rodgers on your fantasy squad, no player on your team is immune to generating zero points.
Brutal matchups like the one Steven Jackson faced last week can cripple the fantasy day of even the most beastly players in the league.
Jackson faced a relentless 49ers front that hasn't allowed a rushing touchdown all season long. Even with Patrick Willis leaving the game with a hamstring injury, the 49ers held the powerful back to 19 rushing yards on 10 carries.
This week features matchups even the most talented players in the league won't be able to overcome. Here are five stars with lousy matchups ahead of them.
Believe it or not, the Browns have the No. 1 pass defense in the entire league, allowing just 173.3 passing YPG.
Some will argue that this is a result of teams not throwing on them, but even if that holds true, the pattern shouldn't change this week against Pittsburgh.
Big Ben hasn't had more than 200 yards in either of his last two matchups. Such will be the case this week.
Donald Brown might not be a superstar, but with a touchdown in his last two games has some owners thinking about striking while the iron is hot and giving him the start.
Brown has been an unheralded viable emergency option in fantasy, scoring a touchdown and/or rushing for over 50 yards in every game in his last five weeks.
That streak ends this week.
Baltimore has an unforgiving defense, with or without No. 52. They have a punishing run defense that has held teams to 88.8 rushing YPG.
It's going to be a long day for the winless Colts and an even longer day for Brown.
A boneheaded decision to ice their own kicker left the Cowboys with a losing result against the Cardinals, but don't let that blind you to the fact that they have one of the scariest defenses in the NFL.
The Cowboys don't have a lock-down secondary, but they've produced a ridiculous 35 sacks this season and they've forced 14 picks this season.
The Giants uncharacteristically have the worst rushing offense in the entire NFL, which makes their one-dimensional offense easy for Rob Ryan to figure out.
Eli Manning only has two games without 250 yards or more this season. He could easily meet his match here.
The San Francisco 49ers haven't allowed a rushing touchdown this season. Beanie Wells has touchdowns in back-to-back games and has over 300 total yards in that span.
Wells is about to hit a brick wall, just as Steven Jackson did last week and Wells did the first time he squared off against the 49ers.
Teams are going to start making an effort to break the 49ers' historic streak and if Willis sits, this would be the week to do it.
Even without him though, Navorro Bowman and the unsung heroes of the 49ers' front will rise to the occasion, and the streaky Cardinals run game will see another dip in production.
Dwayne Bowe has struggled to really get it going this season as it is. Now that he's going to be taking a vacation on Revis Island this week, his efforts to get back on track will prove futile.
The heinous quarterback situation in Kansas City with Tyler Palko now under center only makes Bowe's uphill battle even steeper.
Bowe got off to a hot start, racking up over 100 yards in three of his first five games and scoring four touchdowns through that span.
He hasn't broken the 100-yard mark or found the end zone since. This isn't exactly the week to turn it on, as he's going to be under the watchful eye of the league's best shut-down corner.