The 9-2 49ers can clinch the NFC West title with a win, while the feisty Rams, even at 2-9, hope to make the Niners pop the champagne corks on another day.
The 49ers come into today's game with running back Frank Gore needing just 22 yards to set a new San Francisco career rushing record. Gore also needs only 91 yards to wrap up his fifth 1,000-yard season. Quarterback Alex Smith, meanwhile, will try to hit paydirt again after being shut out of the end zone last week in the Niners' 16-6 loss to the Baltimore Ravens.
On the Rams' side of the ball, running back Steven Jackson will be looking for his fourth 100-yard-plus game after being held to 106 yards total (3.3-yard average) in his last two games. The Rams come in badly depleted by injuries, with quarterback Sam Bradford listed as questionable early this morning on NFL.com.
The big question for today's game: Can the Rams overcome their injury situation and mount a challenge to a highly motivated 49er team? Keep it here, and I'll be updating you with commentary and analysis throughout the game.