The Colts are 20-point underdogs and they have looked absolutely wretched for the past two months. With defensive coordinator Larry Coyer the first casualty of the Colts "oh-fer" year so far, head coach Jim Caldwell may be fighting for his job with this game.
We'll also get our first look at Dan Orlovsky as a starting QB for the Colts. The underwhelming Curtis Painter has been justifiably kicked to curb and now Orlovsky will be trying to avoid being a part of a second 0-16 team.
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Final Score: Colts, 24 - Patriots, 31