With Darren McFadden just getting out of a walking boot and listed as inactive, it's fair to say that he's going to miss his third straight game.
There are a few running backs out there on the waiver wire that may hold you over for this week.
While there are a few names you won't recognize, these RBs have moved up their team's depth chart because of injuries and may have some favorable matchups this week.
They are short-term replacements, so don't expect too much from them for very long.
With the Detroit Lions' starting running back Jahvid Best still out with a concussion, Maurice Morris gets another start.
Last week against the Chicago Bears, he carried the ball 10 times for 44 yards.
This week, Morris gets a chance to run against the Carolina Panthers and the league's 28th-ranked run defense.
Morris should be able to gain close to 100 rushing yards.
With Peyton Hillis and Montario Hardesty out, Chis Ogbonnaya is the Cleveland Browns' only option.
Last week, granted it was against the St. Louis Rams and the league's worst run defense, Ogbonnaya rushed for 90 yards.
This week, Ogbonnaya goes against the Jacksonville Jaguars who have the league's 14th-ranked run defense.
While Reggie Bush is getting his name mentioned the most with his resurgence in the past few games, the Miami Dolphins have quietly switched from Bush being their primary back to a dual backfield.
Rookie Daniel Thomas has been getting an increasing amount of carries through the season.
Last week, Thomas even got the bulk of the carries, three more than Bush.
This week, the Dolphins play the Buffalo Bills, who have been allowing 125 rushing yards per game.
Ahmad Bradshaw is still out with a foot injury and Brandon Jacobs is too inconsistent. That leaves the New York Giants with D.J. Ware.
Ware should take advantage of an inferior Philadelphia Eagles' rushing defense, which ranks 17th in the league.
Kendall Hunter may be someone to keep an eye on. Frank Gore is nursing a bruised knee and with the San Francisco 49ers so ahead of the other teams in their division, there is no need to rush him back.
Hunter might get more and more carries as the season goes on while the 49ers rest Gore for their playoff run.
In spot duty, Hunter has delivered. While only getting around six carries per game, he averages 4.8 yards every time he touches the ball.
This week the 49ers take on the Arizona Cardinals, who rank 21st in the league against the run.