With the Giants down by seven and having just given up a touchdown, Eli looked for Mario Manningham over the middle and the pass was intercepted by Carlos Rogers.
On the next play, Kendall Hunter went 17 yards into the end zone.
Honestly, it's hard to pin the interception only on Eli, considering Manningham clearly stopped at the top of his route when he shouldn't have. The result made Eli look like he was throwing to nobody.
The 14-point deficit proved too much to overcome, though the Giants scored and eventually drove inside the 10-yard line with a chance to tie the game. Justin Smith knocked down a 4th and 2 pass from Eli to Victor Cruz and the game was over.
There is no worse way to lose a game (on a non-scoring play) than a tipped ball at the line of scrimmage.
Here are five things that we learned from this devastating loss.