UFC Fight Club members can take advantage of the pre-sale that begins today at 10 am PT.
Subscribers to the UFC newsletter will be next in line to purchase tickets at 10 am PT on Thursday.
At last, the general public has their shot at tickets this Friday at 10 am PT.
The event takes place inside MGM Grand Garden Arena in Las Vegas one day prior to New Year's Eve on December 30.
Lesnar returns to action for the first time since overcoming a second stint of diverticulitis, while Overeem makes his organizational debut.
The winner of the highly anticipated heavyweight bout receives the opportunity to dethrone the winner of this weekend's UFC on Fox championship matchup between Cain Velasquez and Junior dos Santos.
After dropping his UFC debut to Frank Mir, Lesnar went on to defeat the likes of Randy Couture, Frank Mir (Rematch), Heath Herring, and Shane Carwin to claim and defend the heavyweight championship.
His dominance came to an end at UFC 121 when he met current champion Cain Velasquez, as Lesnar was defeated by first round technical knockout.
Overeem enters the organization after most recently defeating Fabricio Werdum by decision this past June under the Strikeforce banner.
94 percent of the former Strikeforce heavyweight champion and K-1 world grand prix kickboxing champion's wins have come by way of knockout or submission.
At 6'5, 256 pounds, Overeem presents Lesnar with his largest opponent to date and Lesnar returns the favor by welcoming "The Demolition Man" to the Octagon with his superior wrestling.
Needless to say, it'd be wise to get your tickets while they last because MGM Grand Garden Arena will be sold out on New Year's weekend.