Wes Welker vs. New York Jets
What's not to like about the NFL's leading receiver going up against the best cornerback in the game in Darrelle Revis? The two didn't face off much in the first meeting, and Welker caught five passes for 124 yards. Here's to Revis getting more one-on-one time on the Patriots best offensive weapon this Sunday.
Reggie Bush vs. Washington Redskins
Is the light starting to come on for Bush? He has over 250 total yards in his past two games, and the Dolphins are starting to lean on him more and more. The Redskins offer nothing offensively, but their defense can play. Sunday will be a good test as to where Bush is at.
Fred Jackson vs. Dallas Cowboys
The Cowboys have been gashed on the ground in consecutive weeks, as LeSean McCoy went off for 200 total yards before Marshawn Lynch ran for 135 in Week 9. The Cowboys get no rest this Sunday when Fred Jackson comes to Dallas. The Bills need to rebound after falling to 5-3, and Jackson will be the guy they rely on to make that happen.
Andy Dalton vs. Pittsburgh Steelers
Week 10 will be the biggest test of the season for both the 6-2 Bengals and their rookie quarterback. Can the Bengals prove they belong in the tough AFC North? Will Dalton fold against a defense as good as Pittsburgh? There's fascinating storylines galore in this game.
Eli Manning vs. San Francisco 49ers
A red-hot quarterback faces a stifling defense as Manning travels across the country to take on the 49ers. You could make a strong argument that Manning hasn't played this well since the Giants won the Super Bowl in 2007. The 49ers defense, led by inside linebackers Patrick Willis and NaVarro Bowman, have a good case for being the NFL's best defense in 2011.
Aaron Rodgers vs. Minnesota Vikings
Rodgers vs. anyone is an exciting matchup this season. It really hasn't mattered what kind of defense—good or bad—is thrown at Rodgers. With a bye week in between and just three total weeks since these two last played, it'll be interesting to see how the Vikings attack the game's best quarterback.
Calvin Johnson vs. Chicago Bears
The Bears defense is well known for their ability to stop the run and get after the quarterback, but they also do a nice job of eliminating big plays from opposing offenses with their Cover-2 looks. If they take that away from the Lions next Sunday, could we see the worst fantasy output from Johnson this season? No one has been able to stop him so far in 2011.