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Series Record: 43-34-5 Notre Dame
Not hard to pick the top rivalry for this list.
This rivalry features two of the top football programs in NCAA history, with the two schools combining for 22 National Championships.
The rivalry's yearly meeting is always one of the most attended games in college football. The second ever meeting between the teams, a 7-6 affair, had an estimated 120,000 people in attendance. Two years later, the two teams met at Soldier Field in Chicago and played in front of the second largest verified crowd in NCAA history with 112,912 people in the audience.
The two teams have both had their periods of dominance in the rivalry. From 1970-82, the Trojans won 11 of the 13 meetings, however the Fighting Irish responded with 15 straight seasons of defeating Southern California.
In recent years, USC has dominated the rivalry. The Trojans have won eight of the last nine meetings with their lone loss coming last season at the Coliseum in a 20-16 game.
In the latest installment in the legendary rivalry, USC took care of business in South Bend, winning the game 31-17. In the game, the Trojans amassed 443 total yards and forced three turnovers. The Trojans led the entire game, jumping out to a 17-0 lead and never relented.