The No. 12 Virginia Tech Hokies are now 7-1 on the season and are coming off a 30-14 thrashing of Boston College.
Duke, however, continues to prove it's more of a basketball school than a football stalwart. The Blue Devils are 3-4 this season and they've gotten outscored by No. 6 Stanford and Florida State by a combined score of 85-30.
This game is at Wallace Wade Stadium, but that's unlikely to help Duke very much.
Where: Wallace Wade Stadium; Durham, NC
When: Saturday, Oct. 29 at 12:30 p.m. ET
Radio: Virginia Tech IMG Sports Network; Blue Devil IMG Sports Network, Sirius 113 & 191
Betting Line: Virginia Tech -15.5
Who Might Not Play for Virginia Tech:
James Gayle, Questionable
Alonzo Tweedy, Questionable
Jayron Hosley, Questionable
Eric Martin, Questionable
David Wang, Out until mid-November
Who Might Not Play for Duke:
Dave Harding, Questionable
Brandon Connette, Questionable
Lee Butler, Questionable
Josh Snead, Questionable
Key Storyline: Quarterback play.
Duke doesn't have much of a chance in this matchup, but if the Blue Devils are to make a game out of it quarterback Sean Renfree is going to have to play above his ability.
One strength for the Blue Devils is they are ranked 22nd in the nation in passing yards per game, led by Renfree. He's completing nearly 68 percent of his throws for 1,800 yards, but he has to make it count near the goal line.
Virginia Tech quarterback Logan Thomas, however, became the first Hokies quarterback under head coach Frank Beamer to throw for at least 260 yards in three consecutive games. Not only that, the Blue Devils are ranked 102nd in the FBS in pass defense, giving up 264.0 passing yards per game.
Virginia Tech is right on the cusp of the Top 10 of the AP poll and it may be a tough chore to steal the ACC from No. 5 Clemson, so the Hokies can't afford to lose games like this.
It appears Virginia Tech's best chance of getting into a BCS bowl at this point is to win their remaining four games, which shouldn't be that hard considering they play Duke, Georgia Tech, North Carolina and Virginia to end the season.
Virginia Tech Player to Watch: Logan Thomas, QB
Logan Thomas, the successor to Tyrod Taylor, is on a roll his last three games, averaging 286 passing yards per game with six touchdowns to zero interceptions.
Thomas faces a soft Duke pass defense in Week 9 and it would be surprising if he didn't rack up big numbers and points.
Duke Player to Watch: Sean Renfree, QB
Renfree may have completed a high percentage of his throws for a lot of yards, but he can't expect to beat a good defense like VT's if he doesn't punch the ball into the end zone when it matters.
Renfree has five touchdown passes to four interceptions this season.
He's the key for a Blue Devils victory.
Key Matchup: Sean Renfree vs. Virginia Tech pass defense
Most likely it won't be pretty for Renfree against the Hokies defense, but Virginia Tech has suffered a slew of injuries, including to linebackers Bruce Taylor and Jeron Gouveia-Winslow and defensive lineman Antoine Hopkins.
If the Blue Devils stand any chance, they need Renfree to step up big and dominate in the red zone.
Prediction: Virginia Tech 33, Duke 17