San Diego comes in with a 4-2 record and alone in first place in the division, while KC is just one game behind at 3-3, and is looking to build off of a recent three-game winning streak.
Here are six keys to victory for the Chiefs against SD on Monday night.
Unless you have been living under a rock, you might have seen what happened to Chargers QB Philip Rivers in their opening game of the 2010 season.
Bothered by a rather hostile Arrowhead crowd, Rivers and his offensive line were never able to get in sync during the game, as there were several false starts and delay of game penalties.
The Pro Bowl signal caller even kicked the ball at one point, to vent his frustration.
If the Chiefs crowd and defense can get under Rivers' skin again on Monday night, it could be deja vu for the San Diego offense.
Similar to the Chiefs offense, the Chargers have two standout wide receivers that highlight their passing game.
Pro Bowl receiver Vincent Jackson leads the team with 423 receiving yards and four TDs, as veteran Malcolm Floyd is second on the squad with 294 yards and a TD score as well.
With Antonio Gates dealing with hampered by injuries so far this season, Rivers has looked to Jackson and Floyd to help fill the void.
It is very important that KC's secondary doesn't let either of these talented playmakers run all over them in Week 8.
This is something that the Chiefs have done a very good job with this season.
Kansas City's starting QB has only been sacked a total of 10 times in six games, which is outstanding compared to some of the pass rushers that the Chiefs' offensive line has faced so far.
This week presents yet another challenge to the KC O-line in protecting their $63 million dollar man.
San Diego's defense has been averaging nearly two sacks a game and has one of the better pass rushers in the division in outside linebacker Shaun Phillips.
Dwayne Bowe and Steve Breaston have been the best one-two receiving punch in the AFC West so far this season.
Bowe has 496 receiving yards and four touchdowns while Breaston is now up to 293 yards through the air with two scores to go with it.
They have both had 50+ receiving yards in each of their last three games, and seem to only be getting better as the season progresses.
The biggest priority for Chiefs' QB Matt Cassel in this game is to get the ball to the Killer B's, meaning Bowe and Breaston.
Third-year Chiefs head coach Todd Haley has been known to take some risks and use trick plays at different points in games.
This past Sunday, Haley opted to put CB/KR Javier Arenas in the wildcat, only to see the former University of Alabama star score his first rushing touchdown of his pro career.
It was a gutsy move, but it still worked to perfection.
It might not be a bad idea to throw in some trickery against the Chargers again this week, in an effort to throw them off of their game.
Anyone that is familiar with the NFL knows the Arrowhead Stadium is one of the toughest venues to play in all of football.
Just ask Chargers QB Philip Rivers how it was for him in his last visit to Kansas City.
The fans are a big reason why the Chiefs were able to become one of the most dominant home teams in the 90's and also go 7-1 in their backyard a season ago.
Since this will be another nationally televised Monday Night game, KC needs to take full advantage of the noisy Arrowhead crowd that will be working in the favor in this game.