Could NFL Week 6 be the week that one, or both, of the league's undefeated teams fall?
Green Bay seems likely to keep it rolling against the St. Louis Rams, while the Detroit Lions face a tough test against the resurgent San Francisco 49ers to keep their record perfect.
Big divisional battles will also take place between New Orleans and Tampa Bay, while the Philadelphia Eagles try to save their season by keeping pace against the Washington Redskins.
In a season that has seen its share of unpredictability, here are the predictions for every winner in Week 6.
When the St. Louis Rams enter Lambeau Field they will be one the biggest underdogs that the NFL has seen so far this year with the Packers favored by two scores.
There is very good reason for that, since the Rams will not have any solutions for stopping the Packer offense. Rodgers and his army will march down the field and score at will, making it impossible for the Rams to keep pace.
Still, the Packers defense has been teetering on the edge of disaster and Sam Bradford has shown the ability to move the ball when he gets into a rhythm. However, Bradford and the Rams will fall victim to the same opportunistic turnovers that the Packers find a way to force.
PREDICTION: GREEN BAY 38, ST. LOUIS 20
The Pittsburgh Steelers made a huge statement last week, proving that despite a patchwork line and injury-riddled roster, they can score at will and still be a threat in the AFC.
The Jacksonville Jaguars on the other hand are only threatening to get in the way of teams' plans to acquire Andrew Luck.
All of that being taken into consideration, the Steelers should roll in this game and force mistakes by rookie QB Blaine Gabbert. It is unlikely that the Steelers will explode for another offensive effort like last week, but look for the defense to come out and put points on the board to help the Steelers roll.
PREDICTION: PITTSBURGH 27, JACKSONVILLE 10
Coming off the bye week, the Redskins could have their hands full with a desperate Philadelphia Eagles squad.
Despite their defensive struggles, the Eagles have still had no trouble getting to the quarterback, and that could be a recipe for disaster in Washington.
Rex Grossman was shaky at best in his last two games against Dallas and St. Louis, which should be good news for the Eagles. Andy Reid will finally tailor a game plan to help Vick protect the ball and the team will respond with a sorely needed victory.
PREDICTION: PHILADELPHIA 24, WASHINGTON 13
The Detroit Lions are a team riding high on talent but living on the edge in many of their games. In San Francisco, Jim Harbaugh has the 49ers riding high on confidence, allowing talent to shine.
The 49ers are not intimidated by traveling and showed that they can handle talented teams with their thorough dismantling of Tampa Bay.
Detroit is a better team than the Bucs right now, but their flirtation with a perfect season will end this week at the hands of the 49ers in a close one.
PREDICTION: SAN FRANCISCO 31, DETROIT 28
The Atlanta Falcons will get another chance to defend their home turf when Cam Newton and the Panthers come to town.
The Panthers have shown the ability to keep the game close, but haven't been able to finish games off. That will be to the benefit of the Falcons, who were able to jump out early against the Packers, and will do the same this weekend.
This time Matt Ryan and the Falcons will continue to score and outpace the Panthers all game long.
PREDICTION: ATLANTA 34, CAROLINA 24
Is this the week that Curtis Painter and the Indianapolis Colts break through for a victory?
The short answer is no. The Colts missed their golden opportunity to win against the Chiefs last week. Now with a banged up roster facing an improved Bengals defense, the Colts will not find a way to out-duel Andy Dalton and AJ Green.
PREDICTION: CINCINNATI 24, INDIANAPOLIS 13
After a disappointing loss to the Seattle Seahawks, the Giants will continue their home slide when the Buffalo Bills come to town.
The Giants still boast an impressive pass rush, but Fred Jackson gives the Bills a necessary tool in slowing it down. Chan Gailey will tailor his game plan to help keep pressure off of Fitzpatrick and keep the offense on schedule.
The Bills defense is also carving out a niche as one of the games most productive take-away squads, and Eli Manning will give them a chance to protect that reputation.
PREDICTION: BUFFALO 21, NEW YORK 14
The Baltimore Ravens defense is showing no signs of slowing down with age. They are as dominant as they have always been, and that is bad news for the Houston Texans.
The Texans were dealt another crushing blow when they lost Mario Williams to injury, but it will give rookie Brooks Reid a chance to step up. Even if Williams were going to be in the lineup, it won't be enough to slow down Ray Rice and the Ravens offense.
PREDICTION: BALTIMORE 28, HOUSTON 14
The only thing harder than trying to beat the Oakland Raiders the same weekend that Al Davis passed away will be trying to beat the Raiders in their first home game after Al Davis passed away. That is the charge of the Cleveland Browns.
Even without the emotional lift that the Raiders are sure to have, their rushing attack and punishing defense would be too much for Cleveland to overcome. The Raider defensive line will be in Colt McCoy's face all game, while Oakland's offensive line will impose their will as well.
PREDICTION: OAKLAND 31, CLEVELAND 13
The only way to make Tom Brady less effective is to put him on the ground and get him frustrated. The Dallas Cowboys will make that the only goal of DeMarcus Ware, and it is likely that he will succeed.
Tony Romo will continue his roller coaster season by authoring a great performance against a Patriots secondary that has shown the ability to be burned. The difference will come in Jason Garrett keeping a close eye on the game plan and taking the ball out of Romo's hands at the first sign of trouble and handing it to Felix Jones.
PREDICTION: DALLAS 31, NEW ENGLAND 24
Drew Brees and the New Orleans Saints could be the most dangerous team that nobody is talking about. While playing in the relative shadows of Brady and Rodgers, Drew Brees is putting together as impressive a season as he ever has.
The Tampa Bay Buccaneers on the other hand were thoroughly embarrassed by the 49ers last week. Missing LeGarrette Blount will not help them control the game against the Saints, and in the end it will be their undoing.
The Saints will continue to stretch their lead in the NFC South.
PREDICTION: NEW ORLEANS 24, TAMPA BAY 17
No other QB in the league knows the view from the turf like Jay Cutler. He is getting absolutely no help from his offensive line and despite some productive running from Matt Forte, the offense is being severely limited.
Still, the Bears defense can find ways to shut down the Vikings, and Cutler has proven that he can do just enough to score on a few drives. This one will be very close and might come down to which quarterback makes the most mistakes while trying to push the action and win the game.
If that is truly the case, then it is will likely be the Bears defense that gains the upper hand.
PREDICTION: CHICAGO 17, MINNESOTA 10
It is time for the Jets to get right, and a game against the winless Dolphins with Matt Moore at the helm is a perfect fit for that mission.
Brandon Marshall wants to get attention for things that aren't related to scoring touchdowns, and while that is going on, Santonio Holmes and Plaxico Burress will get the attention for doing just the opposite.
PREDICTION: NEW YORK 34, MIAMI 7