Both teams will have their aces on the mound, with Chris Carpenter going against Yovani Gallardo.
Besides home-field advantage and the rally squirrel advantage, St. Louis has a number of factors that will lead to them winning this game.
Let's take a look now at three reasons the St. Louis Cardinals will take a 2-1 lead in the NLCS.
1. Yovani Gallardo is 1-3 against the Redbirds in 2011, 0-3 since August
Gallardo beat the Cardinals early on in the season, but couldn't repeat that success down the stretch.
In his three starts against the Redbirds after August 1, Gallardo was 0-3 with 15 earned runs allowed.
To say the Cardinals had his number would be an understatement.
He's going to have to pitch a lot better than that Wednesday night if he's going to give the Brewers an advantage in this series.
2. Albert Pujols, Rafael Furcal and Matt Holliday have a combined 7 HRs against Gallardo this year
Who will win Game 3 of the NLCS?
Against Gallardo in 2011, three of the Cardinals main hitters have been stellar.
Pujols has three home runs and seven RBIs, Holliday has two home runs and three RBIs and even the normally powerless Furcal has a pair of solo homers against the Brewers ace.
And, with Pujols being on a hot streak, leading back to his HR and three doubles on Monday night, the Cardinals bats should come alive, again, tonight.
It could end up being a long night for the Milwaukee bullpen.
3. Chris Carpenter will be pitching angry
This will be Carpenter's first start since he shutout the Phillies to send the Cardinals to the NLCS.
This is also his first start since Zack Greinke called him "phony" in a press conference.
Carpenter will definitely have that in the back of his head for extra motivation during Wednesday night's game.
He'll be out to show just how real he is, and that could spell problems for the Brew Crew.