It's no secret that there will be players who disappoint each week, because something's bound to give when everyone on the field is a pro at what they do.
The concern thereafter however, is how those players respond when facing adversity, since having the mental toughness to bounce back is what separates the average from the good, and the good from the great.
And with disappointing performances in mind, here are four player guaranteed to have a letdown in Week 6.
Delone Carter: RB, Colts (at Cincinnati)
Even if RB Joseph Addai plays this week at Cincinnati, he's not going to be 100 percent, so that means Delone Carter will get the bulk of the carries.
However, don't expect much from Carter as the Bengals have a Top 10 rush defense and a Top 5 pass defense.
And with all of their injuries, the Colts will be lucky to score one time against one of the league's best defenses.
After this blowout concludes, Carter will have compiled only 50 total yards on 20 touches, and he won't reach the end zone like he did against Kansas City.
Maurice Jones-Drew: RB, Jaguars (at Pittsburgh)
MJD may be one of the best RBs in the game, but it doesn't matter when your starting QB is a rookie with no receiving targets and your team has a passing offense ranked No. 32 in the NFL.
It also doesn't help that he's going up against a much improved Steelers defense that blanketed Titans RB Chris Johnson last week.
Jones-Drew is the Jacksonville offense and Pittsburgh will have at least two spies on him while the other six in the box blitz Gabbert.
Anticipate only 70 total yards and no TDs from MJD this week as Pittsburgh moves to 4-2.
Matt Schaub: QB, Texans (at Baltimore)
He may be one of the better QBs in the game with Andre Johnson playing, but without, Matt Schaub is about average at best.
Now he does have a chance to really prove his worth this week as the Texans play at Baltimore, who has a Top 10 defense.
But with a healthy Ed Reed and no Andre Johnson, Schaub will be lucky to throw for 175 yards and one TD, because the Ravens will force Houston to throw since Johnson is out.
They're going to blitz and shut down Houston's ground game, which in turn will get them at least three turnovers from Schaub.
Michael Vick: QB, Eagles (at Washington)
Through five games Eagles QB Michael Vick has had a solid season thus far. Even though he's thrown seven picks, four of them came last week against a Bills defense that also picked off Tom Brady four times. So in other words, he's in good company.
This week however, Vick goes up against a Redskins defense that he torched by himself last year, but Washington is much improved and hasn't forgotten the 2010 beat-down.
Therefore, if Vick shreds the 'Skins again it will be very surprising.
For one, Washington ranks No. 8 against the pass and No. 6 against the rush, so Philly has their hands full either way.
Plus with the game in our nation's capital, you know the fans are going to be electric.
And unfortunately for The City of Brotherly Love, Philly not only falls again, but Vick accounts for just 200 passing yards, one TD, and throws two picks with a fumble.
Be sure to check out John on Bleacher Report.
And, you can follow him on Twitter @ Sportswriter27.
Like the new article format? Send us feedback!