The storied rivalry between the two sides stretches back decades, and a fiery encounter is expected. Liverpool do not look strong enough to challenge for the title this season, but that won't stop them from trying to derail Manchester United. Bragging rights are at stake in this match—not just between the clubs and the players, but the managers as well.
Here is a look at United's predicted starting 11 against Liverpool.
David de Gea will return in goal against Liverpool.
Rested for United's last match against Norwich because of Spain U-21 call-ups, the Spanish shot-stopper will be itching to go.
Having acted as deputy captain while Nemanja Vidic recovered from injury, Patrice Evra will no longer have that 'burden' this week. However, he will reprise his role at left back.
The Frenchman's link-up play with Ashley Young could be the key to success for United against Liverpool.
Culminating in earning his first cap for England last week, Phil Jones' star has rocketed up to stratospheric heights this season.
With the absence of first choice right-back Rafael, it is likely that Jones will start at right-back for United.
Jonny Evans has been very solid at the back for Manchester United so far this season, and I see him starting for United at center back.
Evans has displayed some good form for United over the past few weeks and is the most experienced of United's young defenders.
This experience will come in handy against Liverpool.
Nemanja Vidic has been out with a calf injury for almost a month, but reports claim the Serbian international will make a return for United against Liverpool.
Having enjoyed a blistering start to the season, Ashley Young's goal scoring and assist making exploits have quieted down a bit. However, his threat on the counter attack remains ever-potent.
The English international's link-up play with Patrice Evra has been instrumental so far this season, and it promises to be a factor against Liverpool.
Barring injury, Nani should play against Liverpool.
The Portuguese winger has been in great form for United so far this season and his unpredictability should help United against Liverpool.
Anderson is Sir Alex Ferguson's first choice central midfielder and will most definitely be starting against Liverpool.
Anderson's contribution to the United team so far has been immense. He has given Sir Alex Ferguson's men a real presence in midfield, scoring goals and providing assists as well.
The man many see as Paul Scholes' successor, Anderson is now a key figure for Manchester United and the way they aim to play.
After recovering from tonsilitis to take part in Scotland's Euro Cup qualification match last week, Darren Fletcher should be fit as a fiddle and ready to play against Liverpool.
Playing in the absence of Tom Cleverley, who looks set to return this week, Fletcher's work in midfield could be the difference between United winning and losing.
After his sending off in England's Euro Cup qualification match last week, Wayne Rooney will be looking to silence his detractors with a performance against Liverpool.
He will be one of the first names on the team sheet.
This is perhaps a surprising choice, as Javier Hernandez is arguably the better partner for Wayne Rooney. However, with news that Sir Alex blocked an England under-21 call-up for Welbeck, it seems likely that he will start this match.