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This game features two of the most surprising teams of the 2011 NFL season. There were some people who expected the Lions to take a huge step forward, but most people expected the 49ers to be in the Andrew Luck sweepstakes.
Look for Matthew Stafford and Calvin Johnson to have a big game in this one. The 49ers defense has been stout against the run, but they are only 23rd in the league against the pass. The Lions feature the sixth-best passing attack in the league based on yards per game.
The best way for the 49ers to slow down the Lions passing attack will be a heavy dose of Frank Gore. The Detroit defense is ranked 17th against the run, and Gore has played much better the last couple of weeks.
The 49ers will keep this game close, but in the end, Stafford and the Lions will make enough plays to get a win.
Lions 30, 49ers 24