It doesn't take a rocket scientist to predict that Tom Brady will have a great day every Sunday, but who else will put up outrageous fantasy numbers in Week 5?
Here is a list of five players who will go off this week, and a few of these guys could even be riding the pine on your team.
So, now it's time to check who made the list of fantasy royalty for this week.
The Buffalo Bills are heading to Philadelphia to face the Eagles on Sunday. Lucky for Fred Jackson that the Eagles are one of three teams in the NFL that have given up over 500 yards to opposing running backs this season.
While Jackson only has had 64 carries on the season, he has racked up 369 yards and four touchdowns on the year. Jackson's yardage is good for fourth best among all the running backs in NFL.
Even more impressive is that the three running backs who have more yardage than Jackson, Darren McFadden, Maurice Jones-Drew and LeSean McCoy, each have at least 11 more carries than Jackson.
Jackson should continue the trend of killing opposing defenses, and he might just be the top producer in Week 5.
If you have Jermaine Gresham on your fantasy team he probably is on the bench, but this week he should definitely get the start.
Gresham embarked on the 2011-2012 season in the right way with six receptions for 68 yards and a touchdown, but he was completely silent the next two weeks with just 59 yards combined.
Last Sunday, Gresham got back on track. He was targeted seven times last week, and he had four receptions for 70 yards with a touchdown.
The Cincinnati Bengals go to Jacksonville to face the Jaguars in Week 5.
After holding the tight ends on the Tennessee Titans to just one catch for nine yards in Week 1, the Jaguars have given up 330 yards and three touchdown in the following three weeks.
Andy Dalton will be looking for Gresham early, and the second-year tight end is a shoo-in for his third touchdown of the season on Sunday.
Philip Rivers has his two starting wide receivers banged up, and Antonio Gates is out with foot problems once again—déjà vu anyone?
Rivers didn't have problems playing with third and fourth-stringers last year, and if need be he won't this season either.
While Rivers isn't having quite as good of a start to the season statistically as he did last year, his team is 3-1 and he is playing pretty well.
In the first four game of 2010, Rivers threw for 1328 yards, nine touchdowns and four interceptions. This season, Rivers has put up 1286 yards, six touchdowns and six interceptions, but in Week 5 Rivers might just have his best game yet.
The San Diego Chargers head east to play an away game against the Denver Broncos on Sunday. The Broncos have given up 1156 passing yards and six touchdowns through the air to opposing quarterback, and Denver has only picked the ball off twice which bodes well for Rivers.
Quarterbacks have averaged 24 fantasy points per game against Denver this season (according to ESPN), but the 43 points Aaron Rodgers dropped on the team in Week 4 has somewhat skewed the Broncos' average.
If you have been disappointed with Rivers not being at the top of his game thus far, expect to be pleasantly surprised with his performance in Week 5.
Julio Jones has really come into his own in recent weeks.
In Week 3 against the Tampa Bay Buccaneers, Jones had six receptions for 115 yards. In Week 4, Jones caught 11 passes for 127 yards against the Seattle Seahawks.
Jones can jump out of the gym, he has unbelievable speed and plays with glue on his gloves. It won't be long before he is one of the most dangerous deep threats in the entire league.
Jones has a pretty good matchup this week against a solid Green Bay Packers secondary that hasn't played up to its potential. The Packers have given up 867 yards and six touchdowns in the first four weeks of the season to wide receivers.
After having breakout games the last two weeks, expect Jones to run wild and grab his first touchdown of the season Sunday.
With a change at quarterback Steve Smith went from fantasy obscurity to fantasy god.
Last season, Smith caught 46 passes for 554 yards and two touchdowns in 14 games.
After just four games this season, Smith has nearly matched his 2010-2011 totals with 24 receptions for 530 yards and two touchdowns.
It's no secret who Cam Newton's favorite receiver is after targeting Smith 41 times already this season.
Smith and the Carolina Panthers are at home against the New Orleans Saints this week. With Drew Brees throwing the ball as well as he ever has you can bet this matchup will be a high-scoring affair.
The Saints have a middle of the road pass defense, too, which makes the matchup all the more enticing.Through four games the Saints have given up 662 yards and five touchdowns to wide receivers.
If you are on the fence about playing Smith this week—you shouldn't be.